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水热合成法利用响应面法（RSM）合成羟基磷灰石粉末。

Hydrothermal synthesis of hydroxyapatite powders using Response Surface Methodology (RSM).

机构信息

Chemical Engineering, Faculty of Engineering Universiti Malaysia Sabah, UMS, Sabah, Malaysia.

Biotechnology, Faculty of Sciences and Natural Resources, Universiti Malaysia Sabah, UMS, Sabah, Malaysia.

出版信息

PLoS One. 2021 May 20;16(5):e0251009. doi: 10.1371/journal.pone.0251009. eCollection 2021.

DOI:10.1371/journal.pone.0251009
PMID:34014966
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8136633/
Abstract

Hydroxyapatite (HAp)-[Ca10 (PO4)6(OH) 2] has a similar chemical composition to bone material, making it the main mineral supplement in bone-making. Due to its high biocompatibility, hydroxyapatite is widely used in the repair of bone deficiencies and in the production of dental or orthopedic implants. In this research, hydroxyapatite nanopowder was synthesized using a hydrothermal technique. Fourier Transform Infrared Spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to investigate the chemical structure and morphology of the synthesized hydroxyapatite powder. X-ray diffraction (XRD) was used to evaluate the phase analysis of HAp nanopowder. In addition, bioactivity HAp assessment was conducted by scanning electron microscopy (SEM) attached with Energy Dispersive X-Ray Spectroscopy (EDX) analysis. Response Surface Methodology (RSM) with central composite design (CCD) was used in order to determine the optimal conditions for yield, size, and crystallinity. Three independent variables (pH, temperature, and hydrothermal treatment time) were investigated. The yield was observed to increase in alkaline conditions; pH showed the greatest influence on the yield, size, and crystallinity of the synthesized hydroxyapatite, based on Analysis of Variance. The results of bioactivity evaluation are showed high bioactivity due to the formation of apatite on the surface of the synthesized nanopowder.

摘要

羟基磷灰石（HAp）-[Ca10（PO4）6（OH）2]的化学成分与骨材料相似，使其成为成骨的主要矿物补充剂。由于其高度的生物相容性，羟基磷灰石被广泛应用于骨缺损的修复和牙科或矫形植入物的生产。在这项研究中，使用水热技术合成了羟基磷灰石纳米粉末。傅里叶变换红外光谱（FTIR）和透射电子显微镜（TEM）用于研究合成的羟基磷灰石粉末的化学结构和形态。X 射线衍射（XRD）用于评估 HAp 纳米粉末的相分析。此外，通过扫描电子显微镜（SEM）和能量色散 X 射线光谱（EDX）分析进行了生物活性 HAp 评估。响应面法（RSM）与中心复合设计（CCD）用于确定产率、尺寸和结晶度的最佳条件。研究了三个独立变量（pH、温度和水热处理时间）。结果表明，在碱性条件下产率增加；基于方差分析，pH 对合成羟基磷灰石的产率、尺寸和结晶度的影响最大。生物活性评估的结果表明，由于合成纳米粉末表面形成了磷灰石，因此具有高生物活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/c19a1bbdb195/pone.0251009.g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/be87a2f98760/pone.0251009.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/e0d925aa782f/pone.0251009.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/88af7fe1bb7e/pone.0251009.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/3cdc7e2bbdec/pone.0251009.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/a364cd37a255/pone.0251009.g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/b51ce6038651/pone.0251009.g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/35762ecd43a7/pone.0251009.g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/bf29783be940/pone.0251009.g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/5cc2ae2b72b9/pone.0251009.g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/d9971b0ca3ae/pone.0251009.g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/40c0014a7bb6/pone.0251009.g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/545ef608dbc2/pone.0251009.g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/f55a3c2a02b2/pone.0251009.g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/c19a1bbdb195/pone.0251009.g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/be87a2f98760/pone.0251009.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/e0d925aa782f/pone.0251009.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/88af7fe1bb7e/pone.0251009.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/3cdc7e2bbdec/pone.0251009.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/a364cd37a255/pone.0251009.g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/b51ce6038651/pone.0251009.g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/35762ecd43a7/pone.0251009.g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/bf29783be940/pone.0251009.g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/5cc2ae2b72b9/pone.0251009.g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/d9971b0ca3ae/pone.0251009.g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/40c0014a7bb6/pone.0251009.g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/545ef608dbc2/pone.0251009.g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/f55a3c2a02b2/pone.0251009.g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b5/8136633/c19a1bbdb195/pone.0251009.g022.jpg

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