恢复期血浆在免疫功能低下和脆弱人群中预防和治疗 SARS-CoV-2 的潜在用途。
Potential use of convalescent plasma for SARS-CoV-2 prophylaxis and treatment in immunocompromised and vulnerable populations.
机构信息
North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy.
Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantua, Italy.
出版信息
Expert Rev Vaccines. 2022 Jul;21(7):877-884. doi: 10.1080/14760584.2021.1932475. Epub 2021 May 27.
Abstract
INTRODUCTION
: The ongoing SARS-CoV-2 pandemic is a serious threat for the health of immunocompromised patients. Among neutralizing antibody-based therapeutics, convalescent plasma containing polyclonal anti-SARS-CoV-2 immunoglobulins has promising results in both congenital and iatrogenic immunodeficiencies in oncohematological and transplant patients.
AREAS COVERED
: This article discusses case reports, case series and controlled studies detailing the efficacy of convalescent plasma in immunocompromised patients.
EXPERT OPINION
: Convalescent plasma, when administered at high neutralizing antibody titers, is a safe and effective treatment for frail immunocompromised patients. Genetic monitoring of refractory patients is recommended to intercept intra-host emergence of SARS-CoV-2 variants.
摘要
简介
持续的 SARS-CoV-2 大流行对免疫功能低下患者的健康构成严重威胁。在基于中和抗体的治疗方法中，含有 SARS-CoV-2 多克隆中和抗体的恢复期血浆在血液肿瘤和移植患者的先天性和医源性免疫缺陷中具有良好的效果。
涵盖领域
本文讨论了详细介绍恢复期血浆在免疫功能低下患者中的疗效的病例报告、病例系列和对照研究。
专家意见
当恢复期血浆中的中和抗体滴度较高时，对虚弱的免疫功能低下患者是一种安全有效的治疗方法。建议对难治性患者进行基因监测，以拦截 SARS-CoV-2 变异株在体内的出现。
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