Ophn1 对前额叶抑制的调节：智力障碍中应激易感性的一种机制。
Ophn1 regulation of prefrontal inhibition: A mechanism for stress susceptibility in intellectual disability.
机构信息
Department of Psychology, McGill University, Montréal, QC, Canada.
Department of Psychology, McGill University, Montréal, QC, Canada; Ludmer Centre for Neuroinformatics and Mental Health, Montréal, QC, Canada.
出版信息
Neuron. 2021 May 19;109(10):1583-1584. doi: 10.1016/j.neuron.2021.04.030.
PMID:34015262
Abstract
Wang et al. (2021) characterize the molecular, cellular, and circuit-level role of Oligophrenin-1 in prefrontal parvalbumin interneurons, demonstrating that loss of Ophn1 function in these neurons is a mechanism for increased susceptibility to stress in intellectual disability caused by OPHN1 mutations.
摘要
Wang 等人（2021 年）描述了少突蛋白 1 在额前叶中间神经元中的分子、细胞和回路水平的作用，表明这些神经元中少突蛋白 1 功能的丧失是 OPHN1 突变引起的智力障碍中对压力易感性增加的一种机制。
Zotero 插件