Ophn1 对前额叶抑制的调节：智力障碍中应激易感性的一种机制。
Ophn1 regulation of prefrontal inhibition: A mechanism for stress susceptibility in intellectual disability.
机构信息
Department of Psychology, McGill University, Montréal, QC, Canada.
Department of Psychology, McGill University, Montréal, QC, Canada; Ludmer Centre for Neuroinformatics and Mental Health, Montréal, QC, Canada.
出版信息
Neuron. 2021 May 19;109(10):1583-1584. doi: 10.1016/j.neuron.2021.04.030.
PMID:34015262
Abstract
Wang et al. (2021) characterize the molecular, cellular, and circuit-level role of Oligophrenin-1 in prefrontal parvalbumin interneurons, demonstrating that loss of Ophn1 function in these neurons is a mechanism for increased susceptibility to stress in intellectual disability caused by OPHN1 mutations.
摘要
Wang 等人（2021 年）描述了少突蛋白 1 在额前叶中间神经元中的分子、细胞和回路水平的作用，表明这些神经元中少突蛋白 1 功能的丧失是 OPHN1 突变引起的智力障碍中对压力易感性增加的一种机制。
相似文献
1
Ophn1 regulation of prefrontal inhibition: A mechanism for stress susceptibility in intellectual disability.Ophn1 对前额叶抑制的调节：智力障碍中应激易感性的一种机制。
Neuron. 2021 May 19;109(10):1583-1584. doi: 10.1016/j.neuron.2021.04.030.
2
Oligophrenin-1 moderates behavioral responses to stress by regulating parvalbumin interneuron activity in the medial prefrontal cortex.少突神经胶质细胞髓磷脂糖蛋白-1通过调节内侧前额叶皮质中小清蛋白中间神经元的活动来调节对应激的行为反应。
Neuron. 2021 May 19;109(10):1636-1656.e8. doi: 10.1016/j.neuron.2021.03.016. Epub 2021 Apr 7.
3
ROCK/PKA Inhibition Rescues Hippocampal Hyperexcitability and GABAergic Neuron Alterations in a Oligophrenin-1 Knock-Out Mouse Model of X-Linked Intellectual Disability.ROCK/PKA 抑制挽救 X 连锁智力障碍寡树突胶质蛋白-1 敲除小鼠模型中海马过度兴奋和 GABA 能神经元改变。
J Neurosci. 2020 Mar 25;40(13):2776-2788. doi: 10.1523/JNEUROSCI.0462-19.2020. Epub 2020 Feb 25.
4
Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb.少突神经胶质细胞蛋白-1调节嗅球中成年新生抑制性中间神经元的数量、形态和突触特性。
Hum Mol Genet. 2016 Dec 1;25(23):5198-5211. doi: 10.1093/hmg/ddw340.
5
Protein Kinase A Deregulation in the Medial Prefrontal Cortex Impairs Working Memory in Murine Oligophrenin-1 Deficiency.内侧前额叶皮质中蛋白激酶A失调损害小鼠少突磷脂糖蛋白-1缺乏时的工作记忆。
J Neurosci. 2017 Nov 15;37(46):11114-11126. doi: 10.1523/JNEUROSCI.0351-17.2017. Epub 2017 Oct 13.
6
Expanding the phenotypic spectrum associated with OPHN1 mutations: Report of 17 individuals with intellectual disability but no cerebellar hypoplasia.扩展与OPHN1突变相关的表型谱：17例智力残疾但无小脑发育不全患者的报告
Eur J Med Genet. 2018 Aug;61(8):442-450. doi: 10.1016/j.ejmg.2018.03.002. Epub 2018 Mar 3.
7
Altered Cl homeostasis hinders forebrain GABAergic interneuron migration in a mouse model of intellectual disability.Cl 动态平衡改变阻碍了智力障碍小鼠模型前脑 GABA 能中间神经元的迁移。
Proc Natl Acad Sci U S A. 2021 Jan 12;118(2). doi: 10.1073/pnas.2016034118.
8
Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability.在X连锁智力障碍小鼠模型中对成年海马神经发生进行药理学挽救
Neurobiol Dis. 2017 Apr;100:75-86. doi: 10.1016/j.nbd.2017.01.003. Epub 2017 Jan 12.
9
The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors.与Rho相关的智力发育迟缓蛋白少突脑苷脂-1通过稳定AMPA受体来控制突触成熟和可塑性。
Genes Dev. 2009 Jun 1;23(11):1289-302. doi: 10.1101/gad.1783809.
10
The RhoGAP activity of OPHN1, a new F-actin-binding protein, is negatively controlled by its amino-terminal domain.一种新的F-肌动蛋白结合蛋白OPHN1的RhoGAP活性受其氨基末端结构域的负调控。
Mol Cell Neurosci. 2003 Aug;23(4):574-86. doi: 10.1016/s1044-7431(03)00078-2.
Zotero 插件