Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
Biomed Pharmacother. 2021 Aug;140:111731. doi: 10.1016/j.biopha.2021.111731. Epub 2021 May 17.
The Ras homolog (Rho) family of small GTPases comprise several proteins with prominent roles in regulation of cell cycle transition, cell migration, and remodeling of actin cytoskeleton. Expression of these proteins is regulated by several factors among them are long non-coding RNAs (lncRNAs). The impact of lncRNAs on Rho GTPases signaling can be exerted through direct modulation of expression of these proteins or influencing expression of miRNAs that negatively regulate Rho GTPases. LINC00974/miR-122/RhoA, MALAT1/miR-429/RhoA, ZFAS1/miR-3924/RhoA/ROCK2, PCAT6/miR-326/RhoA/ROCK, SMILR/miR-141/RhoA/ROCK, DAPK1/miR-182/RhoA, GAS5/miR663a/RhoB, H19/miR-15b/CDC42/PAK1, TDRG1/miR-93/RhoC, TUG1/miR-498/CDC42, UCA1/miR-18a/Cdc42 and UCA1/miR-182/Cdc42 are examples of lncRNAs/miRNAs axes that regulate Rho GTPases. In the present manuscript, we describe the role of lncRNAs on Rho GTPases.
Ras 同源物（Rho）家族的小 GTP 酶包括几种在细胞周期转换、细胞迁移和肌动蛋白细胞骨架重塑的调节中具有重要作用的蛋白质。这些蛋白质的表达受多种因素调节，其中包括长非编码 RNA（lncRNA）。lncRNA 对 Rho GTPases 信号的影响可以通过直接调节这些蛋白质的表达或影响负调控 Rho GTPases 的 miRNA 的表达来发挥。LINC00974/miR-122/RhoA、MALAT1/miR-429/RhoA、ZFAS1/miR-3924/RhoA/ROCK2、PCAT6/miR-326/RhoA/ROCK、SMILR/miR-141/RhoA/ROCK、DAPK1/miR-182/RhoA、GAS5/miR663a/RhoB、H19/miR-15b/CDC42/PAK1、TDRG1/miR-93/RhoC、TUG1/miR-498/CDC42、UCA1/miR-18a/Cdc42 和 UCA1/miR-182/Cdc42 是调节 Rho GTPases 的 lncRNA/miRNA 轴的例子。在本文中，我们描述了 lncRNA 对 Rho GTPases 的作用。
