Ghafouri-Fard Soudeh, Hajiesmaeili Mohammadreza, Shoorei Hamed, Bahroudi Zahra, Taheri Mohammad, Sharifi Guive
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Critical Care Quality Improvement Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Cell Dev Biol. 2021 Jul 22;9:696820. doi: 10.3389/fcell.2021.696820. eCollection 2021.
Stem cells have two important features, namely the ability for self-renewal and the capacity to differentiate into some cell kinds with specialized functions. These two features are also present in cancer stem cells (CSCs). These cells have been detected in almost all kinds of cancers facilitating their tumorigenicity. Molecular cascades that control self-renewal of stem cells, namely the Wnt, Notch, and Hedgehog pathways have been suggested to influence CSCs functions as well. Moreover, non-coding RNAs can regulate function of CSCs. Function of miRNAs in the regulation of CSCs has been mostly assessed in breast cancer and hepatocellular carcinoma. miR-130a-3p, miR-600, miR-590-5p, miR-142-3p, miR-221, miR-222, miR-638, miR-375, miR-31, and miR-210 are among those regulating this feature in breast cancer. Moreover, miR-206, miR-192-5p, miR-500a-3p, miR-125, miR-125b, miR-613, miR-217, miR-194, and miR-494 regulate function of CSCs in hepatocellular carcinoma. DILC, lncTCF7, MUF, HAND2-AS1, MALAT1, DLX6-AS1, HOTAIR, and XIST are among lncRNAs that regulate function of CSCs. In the present paper, we explain the effects of these two classes of non-coding RNAs in the regulation of activity of CSCs.
干细胞具有两个重要特征，即自我更新能力和分化为某些具有特定功能细胞类型的能力。这两个特征在癌症干细胞（CSCs）中也存在。几乎在所有类型的癌症中都检测到了这些细胞，它们促进了肿瘤的发生。据推测，控制干细胞自我更新的分子级联反应，即Wnt、Notch和Hedgehog信号通路，也会影响癌症干细胞的功能。此外，非编码RNA可以调节癌症干细胞的功能。miRNA在癌症干细胞调控中的作用大多在乳腺癌和肝细胞癌中进行了评估。miR-130a-3p、miR-600、miR-590-5p、miR-142-3p、miR-221、miR-222、miR-638、miR-375、miR-31和miR-210是在乳腺癌中调节这一特征的miRNA。此外，miR-206、miR-192-5p、miR-500a-3p、miR-125、miR-125b、miR-613、miR-217、miR-194和miR-494在肝细胞癌中调节癌症干细胞的功能。DILC、lncTCF7、MUF、HAND2-AS1、MALAT1、DLX6-AS1、HOTAIR和XIST是调节癌症干细胞功能的lncRNA。在本文中，我们解释了这两类非编码RNA在调节癌症干细胞活性方面的作用。
