Gol'dberg E D, Zakharova O Iu, Dygaĭ A M
Biull Eksp Biol Med. 1988 Jul;106(7):23-6.
The influence of leu-enkephalin and dalargin on the blood system was studied during immobilization stress in mice. The early transmitted reactions of the peripheral blood were shown to decrease upon single drug infusions after immobilization. At later terms the activation of bone marrow hematopoiesis was not registered in mice receiving opioid peptides in contrast to the control animals. It correlates with drug-induced decrease in the mitotic activity of bone-marrow cells. Suppressive effect of opioids on hematopoiesis during stress was connected with their decreasing effect on corticosteroid level in the animal plasma. The latter can suggest indirect influence of enkephalins on bone marrow hematopoiesis in immobilization stress.
研究了亮氨酸脑啡肽和达乐argin对小鼠制动应激期间血液系统的影响。结果显示，制动后单次输注药物会使外周血的早期传导反应降低。与对照动物相比，在后期，接受阿片肽的小鼠未出现骨髓造血激活。这与药物诱导的骨髓细胞有丝分裂活性降低相关。阿片类药物在应激期间对造血的抑制作用与其降低动物血浆中皮质类固醇水平的作用有关。后者提示脑啡肽在制动应激中对骨髓造血有间接影响。
