Goldberg E D, Dygai A M, Zakharova O, Shakhov V P
Laboratory of Pathophysiology, Research Institute of Tomsk, Scientific Centre of the USSR Academy of Medical Sciences.
Folia Biol (Praha). 1990;36(6):319-31.
The influence of enkephalins on haemopoiesis was studied under conditions of stress. Administration of leu-enkephalin and dalargin to mice subjected to immobilization led to inhibition of proliferation and differentiation of haemopoietic precursor cells and to a reduction in the content of cellular elements of erythroid and granulocyte lineages of haemopoiesis. On the contrary, met-enkephalin produced a stimulating influence on the bone marrow haemopoiesis in stress. The regulatory influence of enkephalins is connected with reduction of glucocorticoid production and inhibition of migration to bone marrow of T-lymphocyte regulators of haemopoiesis of the phenotype Lyt-1+, Lyt-2+ and with the direct action on the bone marrow cells. Participation of endogenous leu-enkephalin in the haemopoiesis regulation in stress takes place at an early stage (the first 24 h) of the general adaptation syndrome formation.
在应激条件下研究了脑啡肽对造血的影响。给遭受固定的小鼠注射亮氨酸脑啡肽和达洛argin，导致造血前体细胞的增殖和分化受到抑制，造血中红细胞系和粒细胞系细胞成分的含量降低。相反，甲硫氨酸脑啡肽对应激状态下的骨髓造血产生刺激作用。脑啡肽的调节作用与糖皮质激素产生减少以及对表型为Lyt-1 +、Lyt-2 +的造血T淋巴细胞调节因子向骨髓迁移的抑制有关，并且与对骨髓细胞的直接作用有关。内源性亮氨酸脑啡肽在应激条件下造血调节中的参与发生在一般适应综合征形成的早期（最初24小时）。
