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[阿片肽对应激状态下骨髓造血的调节作用]

[Regulatory effects of opioid peptides on bone marrow hematopoiesis in stress].

作者信息

Gol'dberg E D, Dygaĭ A M, Zakharova O Iu, Shakhov V P

出版信息

Biull Eksp Biol Med. 1989 Aug;108(8):216-9.

PMID:2804327
Abstract

It was shown that inhibition of bone marrow hyperplasia disappear due to injection of leu-enkephalin and dalargin as well as the increase of plasma leu-enkephalin by means of D-phenylalanine on the immobilized mice. The effect of enkephalin on hematopoietic precursor cells may be realized by inhibition of T-lymphocytes migration to bone marrow. Besides, direct specific influence of dalargin on myelokaryocytes is observed.

摘要

结果表明,注射亮氨酸脑啡肽和达洛啡肽可消除固定化小鼠骨髓增生的抑制,通过D-苯丙氨酸可使血浆亮氨酸脑啡肽增加。脑啡肽对造血前体细胞的作用可能是通过抑制T淋巴细胞向骨髓的迁移来实现的。此外,还观察到达洛啡肽对骨髓有核细胞有直接的特异性影响。

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