Gol'dberg E D, Dygaĭ A M, Zakharova O Iu, Shakhov V P
Biull Eksp Biol Med. 1989 Aug;108(8):216-9.
It was shown that inhibition of bone marrow hyperplasia disappear due to injection of leu-enkephalin and dalargin as well as the increase of plasma leu-enkephalin by means of D-phenylalanine on the immobilized mice. The effect of enkephalin on hematopoietic precursor cells may be realized by inhibition of T-lymphocytes migration to bone marrow. Besides, direct specific influence of dalargin on myelokaryocytes is observed.
结果表明，注射亮氨酸脑啡肽和达洛啡肽可消除固定化小鼠骨髓增生的抑制，通过D-苯丙氨酸可使血浆亮氨酸脑啡肽增加。脑啡肽对造血前体细胞的作用可能是通过抑制T淋巴细胞向骨髓的迁移来实现的。此外，还观察到达洛啡肽对骨髓有核细胞有直接的特异性影响。
