Dzhafarov A I, Magomedov N M, Azimova A M, Alieva N I, Dagkesamanskaia D N
Biull Eksp Biol Med. 1988 Jul;106(7):45-7.
The relationship between lipid peroxidation and rat heart mitochondrial monoamine oxidase activity was studied in experimental myocardial necrosis induced by adrenaline injection. It has been established that both the intensity of peroxidation and the activity of monoamine oxidase in mitochondria from adrenaline-injured rat myocardium were essentially increased. The preliminary administration of antioxidants (vitamin E and ionol) was shown to decrease both the intensity of lipid peroxidation and the activity of monoamine oxidase. It is suggested that intensification of lipid peroxidation which is considered to be the main pathogenic factor in ischemic myocardial injury depends on mitochondrial monoamine oxidase activity. Protective effects of antioxidants are realized by the action on two subsequent chains during the formation of active oxygen forms and destruction of lipid peroxidation products.
在肾上腺素注射诱导的实验性心肌坏死中，研究了脂质过氧化与大鼠心脏线粒体单胺氧化酶活性之间的关系。已经确定，肾上腺素损伤的大鼠心肌线粒体中的过氧化强度和单胺氧化酶活性均显著增加。结果表明，预先给予抗氧化剂（维生素E和羟苯丁酯）可降低脂质过氧化强度和单胺氧化酶活性。有人认为，脂质过氧化的加剧被认为是缺血性心肌损伤的主要致病因素，这取决于线粒体单胺氧化酶的活性。抗氧化剂的保护作用是通过在活性氧形式形成和脂质过氧化产物破坏过程中作用于两个后续链来实现的。
