[Heterogeneity of mouse sarcoma cells based on tumorigenicity determined by the different degree of contact inhibition of cell division].

The mouse CBA sarcoma characterized by great cellular heterogeneity was obtained from spontaneously in vitro transformed embryonic fibroblasts. The clones of the given sarcoma distinct in this property were studied. It was shown that the only feature limiting the growth of clones characterized by weak tumorigenicity was contact inhibition of cellular growth. This property is easily estimated by the in vitro methods.