肥大细胞与肿瘤。体外肿瘤增殖的特异性增强。
Mast cells and tumors. The specific enhancement of tumor proliferation in vitro.
作者信息
Roche W R
出版信息
Am J Pathol. 1985 Apr;119(1):57-64.
Abstract
Mast cells were found to be unique among the peritoneal leukocytes by virtue of their capacity to enhance profoundly the proliferation of a variety of tumors in vitro. This phenomenon occurs at mast cell/tumor ratios which reflect the stoichiometry of host cell/tumor relationships in vivo. The growth factor was found to reside in mast cell granules and was identified as heparin by sequential purification and enzymatic degradation. This cellular interaction was tumor-specific, although isolated granules could enhance fibroblast proliferation. The findings are discussed in relation to previous morphologic studies, reports of in vitro mast-cell-mediated tumor cytotoxicity, and the role of mast cells in angiogenesis and connective tissue proliferation.
摘要
肥大细胞因其在体外能显著增强多种肿瘤的增殖能力，而在腹膜白细胞中显得独特。这种现象发生在肥大细胞与肿瘤的比例上，该比例反映了体内宿主细胞与肿瘤关系的化学计量。生长因子被发现存在于肥大细胞颗粒中，并通过连续纯化和酶降解被鉴定为肝素。这种细胞间相互作用具有肿瘤特异性，尽管分离出的颗粒能增强成纤维细胞增殖。结合先前的形态学研究、体外肥大细胞介导的肿瘤细胞毒性报告以及肥大细胞在血管生成和结缔组织增殖中的作用，对这些发现进行了讨论。
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本文引用的文献
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A method for the determination of heparin in blood.一种测定血液中肝素的方法。
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