Research Laboratory: Education, Motricité, Sport Et Santé, EM2S, LR19JS01, High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia.
University of Grenoble Alpes, AGEIS, Grenoble, France.
Chronobiol Int. 2021 Sep;38(9):1290-1298. doi: 10.1080/07420528.2021.1927069. Epub 2021 May 20.
The present study was designed to assess time-of-day effects on postural balance and symptoms of rheumatoid arthritis (RA) patients. A total of 15 American College of Rheumatology functional class I and II RA patients and 15 healthy controls aged between 45 and 55 (mean age: 50 3) years of age voluntarily participated. We conducted a case-control, repeated-measures in design study. Postural balance, axillary temperature, pain intensity, fatigue, and sleepiness were measured during five test sessions at 06:00, 10:00, 14:00, 18:00, and 22:00 h. Participants were randomized to the order of test sessions, and each session was separated by >36 hours to minimize/eliminate learning effects. Center of pressure area (CoP ( < .001), pain ( < .01), and sleepiness ( < .05) values were significantly higher at 06:00 and 22:00 h compared to 10:00, 14:00, and 18:00 h in the RA group. Fatigue significantly increased ( < .05) at 22:00 h in comparison to 10:00, 14:00, and 18:00 h in the RA group. Axillary temperature was significantly ( < .001) lower at 06:00 and at 22:00 h compared to 10:00, 14:00, and 18:00 h in the RA group. In the control group, there were no significant time-of-day difference in fatigue, but axillary temperature was significantly lower ( < .01) at 06:00 h compared to 10:00 h, 14:00, 18:00, and 22:00 h, sleepiness values were significantly higher ( < .05) at 06:00 and 22:00 h compared to 10:00, 14:00, and 18:00 h, and revealed CoP values were significantly ( < .05) higher at 06:00 h compared to 14:00 h. Finally, in the RA group, significant correlations were found between values of CoP and pain (r = 0.47; < .001), sleepiness (r = 0.39; < .01), fatigue (r = -0.46; < .001), and also axillary temperature (r = -0.35; < .001). Multiple linear regression analysis further indicated that in the RA group, time-of-day variation in postural balance was predicted collectively by that in pain and fatigue (30.7%) (R2 = 0.307; F = 11.53; < .001). Our results first suggest that time-of-day significantly affects postural balance, axillary temperature, pain intensity, fatigue, and sleepiness in RA patients and second that the temporal variation observed in pain, fatigue, and somnolence are concomitant with that observed in postural balance.: RA: Rheumatoid arthritis; H&O questionnaire: Horne and Ostberg questionnaire; PSQI: Pittsburgh sleep quality index; HAQ: Health assessment questionnaire; SF-36: the short form-36; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index; CoP: The Center of foot Pressure; CoP: The Center of foot Pressure area; VAS: The Visual Analogue Scale; KSS: Karolinska Sleepiness Scale.
本研究旨在评估时间对姿势平衡和类风湿关节炎（RA）患者症状的影响。共有 15 名美国风湿病学会功能分类 I 和 II 级 RA 患者和 15 名年龄在 45 至 55 岁（平均年龄：50 ± 3 岁）之间的健康对照者自愿参加。我们进行了病例对照、重复测量设计的研究。在 06:00、10:00、14:00、18:00 和 22:00 五个测试时段测量了姿势平衡、腋窝温度、疼痛强度、疲劳和嗜睡。参与者随机分配到测试时段的顺序，每个时段之间间隔>36 小时，以最小化/消除学习效应。RA 组在 06:00 和 22:00 时的压力中心面积（CoP <.001）、疼痛（ <.01）和嗜睡（ <.05）值显著高于 10:00、14:00 和 18:00 时。与 10:00、14:00 和 18:00 时相比，RA 组在 22:00 时的疲劳显著增加（ <.05）。与 10:00、14:00 和 18:00 时相比，RA 组在 06:00 和 22:00 时的腋窝温度显著降低（ <.001）。在对照组中，疲劳没有明显的时间差异，但与 10:00 时相比，06:00 时的腋窝温度显著降低（ <.01），14:00、18:00 和 22:00 时，嗜睡值显著升高（ <.05），06:00 和 22:00 时，与 10:00、14:00 和 18:00 时相比，CoP 值显著升高（ <.05），最后，在 RA 组中，CoP 值与疼痛（r = 0.47； <.001）、嗜睡（r = 0.39； <.01）、疲劳（r = -0.46； <.001）之间存在显著相关性，也与腋窝温度（r = -0.35； <.001）。多元线性回归分析进一步表明，在 RA 组中，姿势平衡的日间变化由疼痛和疲劳（30.7%）（R2 = 0.307；F = 11.53； <.001）共同预测。我们的研究结果首次表明，时间对 RA 患者的姿势平衡、腋窝温度、疼痛强度、疲劳和嗜睡有显著影响，其次，观察到的疼痛、疲劳和嗜睡的时间变化与观察到的姿势平衡变化相一致。
