Clinic for Emergency Medicine, University Hospital Jena, Friedrich Schiller University, Am Klinikum 1, 07747, Jena, Germany.
Faculty of Medicine, Department of Statistics, University of Salamanca, Calle Espejo 2, 37007, Salamanca, Spain.
J Orthop Surg Res. 2021 May 20;16(1):324. doi: 10.1186/s13018-021-02315-7.
Two minimally invasive approaches showed some advantages in outcomes compared to conventional approaches (CAs)-the direct anterior approach (DAA) and the supercapsular percutaneously assisted approach in THA (SuperPATH). To the best of our knowledge, DAA and SuperPATH have never been compared, neither in clinical studies, nor in a meta-analysis. To conduct a systematic review and network meta-analysis of randomized controlled trials comparing short-term outcomes of DAA and SuperPATH in total hip joint arthroplasty (THA).
A systematic literature search up to May 2020 was performed to identify randomized controlled trials (RCTs) comparing SuperPATH with CAs and DAA with CAs in THA. We measured surgical, functional, and radiological outcomes. A network meta-analysis, using frequentist methods, was performed to assess treatment effects between DAA and SuperPATH. Information was borrowed from the above-mentioned RCTs, using the CA group as a common comparator.
A total of 16 RCTs involving 1392 patients met the inclusion criteria, three trials with a level I evidence, 13 trials with a level II evidence. The overall network meta-analysis showed that SuperPATH reduced operation time (fixed effect model: MD = 12.8, 95% CI 9.9 to 15.7), incision length (fixed effect model: MD = 4.3, 95% CI 4.0 to 4.5; random effect model: MD = 4.3, 95% CI 0.2 to 8.4), intraoperative blood loss (fixed effect model: MD = 58.6, 95% CI 40.4 to 76.8), and early pain intensity (VAS 1 day postoperatively with a fixed effect model: MD = 0.8, 95% CI 0.4 to 1.2). The two approaches did not differ in acetabular cup positioning angles and in functional outcome.
Our overall findings suggested that the short-term outcomes of THA through SuperPATH were superior to DAA. SuperPATH showed better results in decreasing operation time, incision length, intraoperative blood loss, and early pain intensity. DAA and SuperPATH were equal in functional outcome and acetabular cup positioning.
与传统入路(CA)相比,两种微创入路(DAA 和经皮SuperPATH 入路)在髋关节置换术(THA)中显示出一些优势。据我们所知,DAA 和 SuperPATH 从未在临床研究或荟萃分析中进行过比较。进行了一项系统的文献检索,以评估直接前路(DAA)和 SuperPATH 在全髋关节置换术中的短期疗效。
对截止到 2020 年 5 月的文献进行了系统检索,以确定比较 SuperPATH 与 CA 和 DAA 与 CA 的随机对照试验(RCT)。我们测量了手术、功能和影像学结果。采用基于贝叶斯方法的网络荟萃分析来评估 DAA 和 SuperPATH 之间的治疗效果。使用上述 RCT 中的信息,以 CA 组作为共同对照。
共纳入 16 项 RCT 共 1392 例患者,其中 3 项研究为 I 级证据,13 项研究为 II 级证据。总体网络荟萃分析显示,SuperPATH 可缩短手术时间(固定效应模型:MD=12.8,95%CI 9.9 至 15.7)、切口长度(固定效应模型:MD=4.3,95%CI 4.0 至 4.5;随机效应模型:MD=4.3,95%CI 0.2 至 8.4)、术中失血量(固定效应模型:MD=58.6,95%CI 40.4 至 76.8)和术后第 1 天的早期疼痛强度(采用固定效应模型:VAS 0.8,95%CI 0.4 至 1.2)。两种方法在髋臼杯定位角度和功能结果方面无差异。
我们的综合研究结果表明,SuperPATH 治疗 THA 的短期效果优于 DAA。SuperPATH 在缩短手术时间、切口长度、术中失血量和减轻早期疼痛强度方面效果更好。DAA 和 SuperPATH 在功能结果和髋臼杯定位方面相当。