CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India.
CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Trends Genet. 2021 Sep;37(9):776-779. doi: 10.1016/j.tig.2021.05.001. Epub 2021 May 17.
Next-generation sequencing (NGS) has identified disease hallmarks and catalogued a vast reservoir of genetic information from humans and other species. Precise nucleotide-interrogation properties of clustered regularly interspaced short palindromic repeats (CRISPR) proteins have been harnessed to rapidly identify DNA-RNA signatures for diverse applications, bypassing the cost and turnaround times associated with diagnostic NGS.
下一代测序 (NGS) 已经确定了疾病特征，并从人类和其他物种中编目了大量的遗传信息。通过利用规律成簇间隔短回文重复序列 (CRISPR) 蛋白的精确核苷酸探测特性，可以快速识别用于各种应用的 DNA-RNA 特征，从而绕过与诊断 NGS 相关的成本和周转时间。
