Pomeranz B, Bibic L
Department of Zoology, University of Toronto, Ont., Canada.
Brain Res. 1988 Jun 14;452(1-2):227-31. doi: 10.1016/0006-8993(88)90027-3.
Rats were anesthetized with a continuous infusion of pentobarbital. First we showed that electroacupuncture (EA) suppressed the tail flick nociceptive reflex. Naltrexone (a long acting opiate antagonist) was given either intravenously or intrathecally to attempt to block this EA effect. The naltrexone prevented this EA effect when injected before the onset of EA treatment, but failed to reverse the EA effects when injected immediately after termination of EA treatment. We discuss the possibility that the endorphins set up a cascade effect whereby the subsequent EA suppression of tail flick is no longer dependent on endorphin and hence cannot be affected by opiate antagonists. This finding may clarify some of the confusion in the acupuncture endorphin literature.
大鼠通过持续输注戊巴比妥进行麻醉。首先，我们表明电针（EA）抑制了甩尾伤害性反射。纳曲酮（一种长效阿片拮抗剂）通过静脉内或鞘内给药，试图阻断这种电针效应。当在电针治疗开始前注射时，纳曲酮可预防这种电针效应，但在电针治疗结束后立即注射时，未能逆转电针效应。我们讨论了内啡肽产生级联效应的可能性，即随后电针对甩尾的抑制不再依赖于内啡肽，因此不受阿片拮抗剂的影响。这一发现可能会澄清针灸内啡肽文献中的一些混淆之处。
