Pomeranz B, Nguyen P
Neurosci Lett. 1987 Jun 26;77(3):316-20. doi: 10.1016/0304-3940(87)90520-9.
Using noxious heat-evoked tail flick in rats anesthetized with pentobarbital infusion, we studied the effects of diazepam applied intrathecally. This drug caused a marked suppression of nociceptive reflexes in a dose-dependent manner. In addition, a small non-suppressive dose of diazepam potentiated electroacupuncture effects. These results are discussed in terms of gamma-aminobutyric acid (GABA) since it is known that diazepam enhances binding of GABA to its receptor and hence potentiates inhibitory effects of GABA in the spinal cord. The possible synergism of diazepam and pentobarbital is also discussed.
在用戊巴比妥持续输注麻醉的大鼠身上，通过有害热诱发的甩尾反应，我们研究了鞘内注射地西泮的效果。该药物以剂量依赖的方式显著抑制伤害性反射。此外，小剂量无抑制作用的地西泮可增强电针效果。鉴于已知地西泮可增强γ-氨基丁酸（GABA）与其受体的结合，从而增强GABA在脊髓中的抑制作用，因此从GABA的角度对这些结果进行了讨论。同时也讨论了地西泮与戊巴比妥可能存在的协同作用。
