Zhou Quan, Cao Fan-Hua, Liu Hui, Zuo Man-Zhen
Department of Gynecology and Obstetrics, The People's Hospital of China Three Gorges University/The First People's Hospital of Yichang Yichang 443000, Hubei, P. R. China.
Department of Nephrology, Traditional Chinese Medicine Hospital of China Three Gorges University/Yichang Hospital of Traditional Chinese Medicine Yichang 443000, Hubei, China.
Am J Transl Res. 2021 Apr 15;13(4):2041-2059. eCollection 2021.
Gynecologic cancer is a serious global healthcare issue with high rates of mortality and morbidity. In recent years, tumor immunity and immunotherapy have attracted extensive attention for treatment of gynecological cancers. Indoleamine 2, 3-dioxygenase 1 (IDO1) plays a critical role in cancer immune escape, and its inhibition has been explored for immune-targeted therapies for many malignancies. However, knowledge about IDO1 involvement in the pathogenesis of gynecological cancers and its therapeutic potential is still evolving. In the current study, we integrated bioinformatics analysis of the prognostic value and immune function of IDO1 in gynecologic malignancies using Oncomine, GEPIA, HPA, TIMER, TISIDB, SurvExpress and Metascape database. Comprehensive analysis revealed that the transcription levels of IDO1 were significantly overexpressed in patients with gynecologic cancers, and IDO1-co-expressed gene signatures may be useful potential prognostic markers for gynecologic cancers. Furthermore, increased IDO1 expression correlated with immune infiltration cells, immune marker sets, and immunomodulators in gynecological cancers. These findings suggest that IDO1 plays an important role in immune infiltration and could potentially be an immunotherapeutic target for gynecological cancers. However, future large-scale and comprehensive research is required to validate our results.
妇科癌症是一个严重的全球医疗保健问题，死亡率和发病率都很高。近年来，肿瘤免疫和免疫疗法在妇科癌症治疗方面引起了广泛关注。吲哚胺2,3-双加氧酶1（IDO1）在癌症免疫逃逸中起关键作用，其抑制作用已被探索用于多种恶性肿瘤的免疫靶向治疗。然而，关于IDO1参与妇科癌症发病机制及其治疗潜力的认识仍在不断发展。在本研究中，我们使用Oncomine、GEPIA、HPA、TIMER、TISIDB、SurvExpress和Metascape数据库，对IDO1在妇科恶性肿瘤中的预后价值和免疫功能进行了生物信息学分析。综合分析显示，IDO1的转录水平在妇科癌症患者中显著过表达，IDO1共表达基因特征可能是妇科癌症有用的潜在预后标志物。此外，IDO1表达增加与妇科癌症中的免疫浸润细胞、免疫标志物集和免疫调节剂相关。这些发现表明，IDO1在免疫浸润中起重要作用，并可能成为妇科癌症的免疫治疗靶点。然而，未来需要大规模和全面的研究来验证我们的结果。
