Zhang Xilan, Nie Dengfeng, Zhang Li, Liu Xiaojun
Department of Pathology, Dongying Second People's Hospital Dongying 257335, Shandong Province, China.
Physical Examination Center, Dongying Second People's Hospital Dongying 257335, Shandong Province, China.
Am J Transl Res. 2021 Apr 15;13(4):2849-2857. eCollection 2021.
This study aimed at exploring the diagnostic values and pathological conditions of serum HGF and CA199 in endometriosis (EMT).
From May 2017 to January 2019, 86 patients with EMT, who were admitted to our hospital, were grouped as Group B, whereas 78 healthy women undergoing physical examinations during the same period were grouped as Group A. Serum HGF and CA199 levels in both groups were detected to analyze their diagnostic values for EMT and their relationships with clinical data.
Compared with those in Group A, both serum HGF and CA199 expression elevated significantly in Group B (P<0.05). Their expression was correlated with the age, course of disease, number of nodules and infiltration depth of the patients (P<0.05). Besides, their expression was remarkably higher in patients with stages III ± IV than that in patients with stages I ± II (P<0.05). According to the Kaplan-Meier curves for tumor-free survival, the high expression of HGF and CA199 was related to the poor prognosis of the patients (P<0.05). According to the COX regression analysis for risk factors, the number of nodules, infiltration depth, American Fertility Society (AFS) staging, HGF and CA199 were the independent risk factors of EMT recurrence (P<0.05).
HGF and CA199 increase in patients with EMT, and can be used as the biomarkers for diagnosing the disease and predicting its prognosis.
本研究旨在探讨血清肝细胞生长因子（HGF）和糖类抗原199（CA199）在子宫内膜异位症（EMT）中的诊断价值及病理情况。
选取2017年5月至2019年1月我院收治的86例EMT患者作为B组，同期78例健康体检女性作为A组。检测两组血清HGF和CA199水平，分析其对EMT的诊断价值及其与临床资料的关系。
与A组相比，B组血清HGF和CA199表达均显著升高（P<0.05）。其表达与患者年龄、病程、结节数量及浸润深度相关（P<0.05）。此外，Ⅲ±Ⅳ期患者的表达明显高于Ⅰ±Ⅱ期患者（P<0.05）。根据无瘤生存的Kaplan-Meier曲线，HGF和CA199高表达与患者预后不良相关（P<0.05）。根据COX危险因素回归分析，结节数量、浸润深度、美国生育协会（AFS）分期、HGF和CA199是EMT复发的独立危险因素（P<0.05）。
EMT患者血清HGF和CA199升高，可作为诊断该病及预测预后的生物标志物。
