The Second Affiliated Hospital of Guangzhou Medical University, Department of Radiology, Guangzhou, China.
Department of Emergency, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou , China.
Cell Mol Biol (Noisy-le-grand). 2021 Aug 31;67(2):95-100. doi: 10.14715/cmb/2021.67.2.14.
To explore the diagnostic value of MRI-DWI signal intensity value combined with serum PGI. PGII and CA199 in early gastric cancer. Sixty cases of gastric cancer patients admitted to our hospital from December 2019 to December 2020 were selected as the gastric cancer group and 80 cases of healthy volunteers who underwent physical examination in our hospital during the same period were selected as the healthy group. All the 60 patients underwent MRI-DWI examination, and the pathological diagnosis results were regarded as the gold standard. MRI-DWI images, MRI-DWI signal intensity values of patients with different degrees of gastric cancer differentiation. Serum PGI, PGII and CA199 levels of subjects in the two groups were compared. AUC was used to evaluate the diagnostic value of MRI-DWI signal intensity value combined with serum PGI, PG II and CA199 for early gastric cancer. In the healthy group, T1W1 showed relatively uniform low signal intensity. While T2WI showed no significant increase in signal intensity. In the gastric cancer group. There was diffuse gastric wall thickening, local thickening or mass formation; T1WI and WATS showed slightly lower signal intensity in the lesion area. T2WI, FLAIR and B-TFE showed slightly uneven or moderately increased signal intensity. DWI showed limited diffusion, and the signal intensity increased uniformly or more uniformly, and the range of increase was clear. The signal intensity of MRI-DWI was 89.12 ± 8.14 in patients with low differentiation, 82.17 ± 6.35 in patients with moderate differentiation, and 74.52 ± 4.53 in patients with high differentiation. There were significant differences in the signal intensity of MRI-DWI among the three groups, and the difference was statistically significant (F=12.214, P <0.05). Serum PGI levels of subjects in the gastric cancer group were significantly lower than those in the healthy group, and the levels of PGII and CA199 were significantly higher than that in the healthy group, with statistical significance (P <0.05). The AUC, sensitivity and specificity of MRI-DWI signal intensity value and serum PGI, PGII and CA199 combined indexes in the diagnosis of gastric cancer were significantly higher than those of the independent indexes, with statistical significance (P <0.05). Conclusion: MRI-DWI signal strength value, serum PGI, PGII and CA199 levels are closely related to the occurrence and development of early gastric cancer. The combined detection and diagnosis efficiency is higher, which is helpful to improve the detection rate of early gastric cancer and is worthy of extensive clinical application.
探讨 MRI-DWI 信号强度值联合血清 PGⅠ、PGⅡ和 CA199 对早期胃癌的诊断价值。方法：选取 2019 年 12 月至 2020 年 12 月我院收治的 60 例胃癌患者为胃癌组，同期在我院体检的 80 例健康志愿者为健康组。所有 60 例患者均进行 MRI-DWI 检查，以病理诊断结果为金标准。比较两组受试者的 MRI-DWI 图像、不同分化程度胃癌患者的 MRI-DWI 信号强度值、血清 PGⅠ、PGⅡ和 CA199 水平。采用 AUC 评价 MRI-DWI 信号强度值联合血清 PGⅠ、PGⅡ和 CA199 对早期胃癌的诊断价值。结果：健康组 T1W1 呈相对均匀的低信号强度，而 T2WI 信号强度无明显增高。胃癌组弥漫性胃壁增厚，局部增厚或肿块形成；病变区 T1WI 和 WATS 呈稍低信号强度，T2WI、FLAIR 和 B-TFE 呈稍不均匀或中度增高信号强度。DWI 呈受限扩散，信号强度均匀或更均匀增加，增加范围清晰。低分化患者 MRI-DWI 信号强度为 89.12±8.14，中分化患者为 82.17±6.35，高分化患者为 74.52±4.53。三组间 MRI-DWI 信号强度差异有统计学意义（F=12.214，P<0.05）。胃癌组患者血清 PGⅠ水平明显低于健康组，PGⅡ和 CA199 水平明显高于健康组，差异有统计学意义（P<0.05）。MRI-DWI 信号强度值与血清 PGⅠ、PGⅡ和 CA199 联合指标对胃癌的诊断 AUC、敏感度和特异度明显高于各独立指标，差异有统计学意义（P<0.05）。结论：MRI-DWI 信号强度值、血清 PGⅠ、PGⅡ和 CA199 水平与早期胃癌的发生发展密切相关，联合检测和诊断效率更高，有助于提高早期胃癌的检出率，值得广泛临床应用。
