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从多孔颗粒技术到定制用于肺部给药的气凝胶的途径。

A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration.

作者信息

Duong Thoa, López-Iglesias Clara, Szewczyk Piotr K, Stachewicz Urszula, Barros Joana, Alvarez-Lorenzo Carmen, Alnaief Mohammad, García-González Carlos A

机构信息

Department of Pharmacology, Pharmacy and Pharmaceutical Technology, I+D Farma group (GI-1645), Faculty of Pharmacy, and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

Faculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, Krakow, Poland.

出版信息

Front Bioeng Biotechnol. 2021 May 4;9:671381. doi: 10.3389/fbioe.2021.671381. eCollection 2021.

DOI:10.3389/fbioe.2021.671381
PMID:34017828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8129550/
Abstract

Pulmonary drug delivery has recognized benefits for both local and systemic treatments. Dry powder inhalers (DPIs) are convenient, portable and environmentally friendly devices, becoming an optimal choice for patients. The tailoring of novel formulations for DPIs, namely in the form of porous particles, is stimulating in the pharmaceutical research area to improve delivery efficiency. Suitable powder technological approaches are being sought to design such formulations. Namely, aerogel powders are nanostructured porous particles with particularly attractive properties (large surface area, excellent aerodynamic properties and high fluid uptake capacity) for these purposes. In this review, the most recent development on powder technologies used for the processing of particulate porous carriers are described via updated examples and critically discussed. A special focus will be devoted to the most recent advances and uses of aerogel technology to obtain porous particles with advanced performance in pulmonary delivery.

摘要

肺部给药在局部和全身治疗方面都有公认的益处。干粉吸入器（DPI）是方便、便携且环保的设备，正成为患者的最佳选择。为DPI量身定制新型制剂，即多孔颗粒形式，在药物研究领域中很受关注，以提高给药效率。人们正在寻找合适的粉末技术方法来设计此类制剂。具体而言，气凝胶粉末是具有特别吸引人特性（大表面积、优异的空气动力学特性和高吸液能力）的纳米结构多孔颗粒，适用于这些目的。在这篇综述中，通过最新实例描述并批判性地讨论了用于加工颗粒状多孔载体的粉末技术的最新进展。将特别关注气凝胶技术的最新进展及其在肺部给药中获得具有先进性能的多孔颗粒的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/970d/8129550/7ce38bce1619/fbioe-09-671381-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/970d/8129550/8506884c8b03/fbioe-09-671381-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/970d/8129550/7ce38bce1619/fbioe-09-671381-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/970d/8129550/033749b1193d/fbioe-09-671381-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/970d/8129550/2e67a5ad5aea/fbioe-09-671381-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/970d/8129550/03ddbc79cdd2/fbioe-09-671381-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/970d/8129550/8506884c8b03/fbioe-09-671381-g008.jpg
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