School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China.
School of Instrumentation Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.
J Mater Chem B. 2021 Jun 3;9(21):4380-4389. doi: 10.1039/d1tb00544h.
There is great potential for photodynamic therapy (PDT)-enhanced photothermal therapy (PTT) to be used for tumor therapy, especially for the single material-mediated process that could greatly simplify the experimental arrangements. This study presents a new cancer phototherapeutic agent consisting of low-work-function lanthanum hexaboride particles, which are excellent light absorbers in the near-infrared (NIR) region. The photothermal effect and reactive oxygen species production were realized by LaB6 under NIR light irradiation. Theoretical calculations based on density functional theory confirmed that the strong NIR light absorption by LaB6 was attributed to the local plasmonic resonance effect and the excellent photodynamic effect derived from the low work function. In vivo treatment of HepG2 tumor-bearing mice revealed that LaB6-mediated phototherapy resulted in excellent tumor inhibitory effects, and no adverse effects on mice were observed. These results indicate that LaB6 is a promising phototherapeutic agent for cancer synergetic phototherapy.
光动力疗法（PDT）增强光热疗法（PTT）在肿瘤治疗中具有巨大的潜力，特别是对于单一材料介导的过程，可以大大简化实验安排。本研究提出了一种由低功函数六硼化镧颗粒组成的新型癌症光疗剂，它是近红外（NIR）区域的优秀光吸收剂。LaB6 在近红外光照射下实现了光热效应和活性氧物质的产生。基于密度泛函理论的理论计算证实，LaB6 对近红外光的强吸收归因于局域等离子体共振效应和低功函数带来的优异光动力效应。在荷 HepG2 肿瘤小鼠的体内治疗中，发现 LaB6 介导的光疗导致了优异的肿瘤抑制效果，并且对小鼠没有观察到不良反应。这些结果表明，LaB6 是一种很有前途的癌症协同光疗的光疗剂。
