Ören Oğuz, Haki Cemile, Kaya Halil, Yüksel Melih
Department of Emergency Medicine,University of Health Sciences, Yüksek İhtisas Training and Research Hospital, Bursa, Turkey.
Department of Neurology, University of Health Sciences, Yüksek İhtisas Training and Research Hospital, Bursa, Turkey.
Neurol Sci. 2022 Jan;43(1):435-440. doi: 10.1007/s10072-021-05326-8. Epub 2021 May 21.
Stroke is one of the most common causes of morbidity and mortality. The need for additional objective parameters as well as the existing criteria continues for eligible patients. The objective of this study is to determine whether the baseline neutrophil/lymphocyte ratio (NLR) predicts symptomatic intracranial hemorrhage (SICH) due to intravenous thrombolytic therapy.
One hundred thirty-three consecutive patients aged 18 years and over who were admitted to the emergency department of a training and research hospital for acute ischemic stroke and underwent intravenous thrombolytic therapy were retrospectively analyzed. For the definition of SICH, European Cooperative Acute Stroke Study III (ECASS III) classification was accepted.
When the groups with and without intracranial hemorrhage were compared, there was a significant difference in terms of the initial National Institutes of Health Stroke Scale (NIHSS) score (p < 0.006), glucose level (p < 0.018), and systolic blood pressure (SBP) (p < 0.050). The NLR value of the patients ranged from 0.47 to 13.74. In the group with SICH, NLR was found to be higher but not statistically significant. (p = 0.125).
For predicting SICH, NLR did not provide strong specificity and sensitivity. A precise cut-off value could not be found to predict the hemorrhagic transformation.
中风是发病和死亡的最常见原因之一。对于符合条件的患者，仍需要额外的客观参数以及现有标准。本研究的目的是确定基线中性粒细胞/淋巴细胞比值（NLR）是否可预测静脉溶栓治疗所致的症状性颅内出血（SICH）。
回顾性分析了133例年龄在18岁及以上、因急性缺血性中风入住一家培训和研究医院急诊科并接受静脉溶栓治疗的连续患者。对于SICH的定义，采用欧洲急性卒中协作研究III（ECASS III）分类。
比较有颅内出血和无颅内出血的两组时，初始美国国立卫生研究院卒中量表（NIHSS）评分（p < 0.006）、血糖水平（p < 0.018）和收缩压（SBP）（p < 0.050）方面存在显著差异。患者的NLR值范围为0.47至13.74。在发生SICH的组中，NLR较高，但无统计学意义（p = 0.125）。
对于预测SICH而言，NLR未提供较强的特异性和敏感性。未找到预测出血性转化的精确临界值。
