Zheng Zhi-Yao, Jin Yu-Ming, Jin Si-Yi, Ke Bo-Wen
West China School of Medicine, Sichuan University, Chengdu 610041, China.
Laboratory of Anesthesiology & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2021 May;52(3):396-401. doi: 10.12182/20210560102.
Carbon monoxide (CO) is an endogenous gasotransmitter produced by the degradation of heme in the presence of heme oxygenase (HO) in mammals. It has been demonstrated that CO participates in a variety of physiological activities and pathological processes, and is closely related to cell protection and homeostasis maintenance in organ tissues. It has been shown by a growing number of studies that CO may play a regulatory and interventional role in the process of the occurrence and development of pain through a variety of mechanisms of action. However, its mechanism of action is still not fully understood and the uncontrollable factors concerning CO administration also placed considerable limitation to its application. This paper reviews the potential targets and pathways of CO in pain regulation and discusses the challenges and opportunities in the clinical application of CO in order to provide suggestions for further exploration and development of CO analgesics.
一氧化碳（CO）是哺乳动物体内在血红素加氧酶（HO）存在的情况下由血红素降解产生的一种内源性气体递质。已经证明，CO参与多种生理活动和病理过程，并且与器官组织中的细胞保护和内环境稳态维持密切相关。越来越多的研究表明，CO可能通过多种作用机制在疼痛的发生和发展过程中发挥调节和干预作用。然而，其作用机制仍未完全了解，并且与CO给药相关的不可控因素也对其应用造成了相当大的限制。本文综述了CO在疼痛调节中的潜在靶点和途径，并讨论了CO临床应用中的挑战和机遇，以便为进一步探索和开发CO镇痛药提供建议。
