Plöckinger Ursula
Interdisziplinäres Stoffwechsel-Centrum: Endokrinologie, Diabetes und Stoffwechsel, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Wien Klin Wochenschr. 2007;119(19-20):570-2. doi: 10.1007/s00508-007-0879-z.
Gastric neuroendocrine tumours (NET) are rare. Clinically they are classified in tumours type 1 to 3. The histological classification is according to the WHO 2000 classification for endocrine tumours. NET type 1 occur in coincidence with chronic atrophic gastritis, as single or multiple small tumours. The prognosis of type 1 tumours is excellent, with no tumour related death reported during follow-up. NET type 2 are part of the MEN-1 syndrome. These tumours may be more aggressive and even develop metastasis. However, in most patients with MEN-1 the prognosis is due to other manifestations of the disease as duodenal or pancreatic neuroendocrine tumours. Gastric neuroendocrine tumours type 3 are sporadic tumours without relationship to other gastric pathology. They tend to occur earlier, without sex preference. These tumours may develop an aggressive course, with metastatic disease and an overall poor prognosis. Thus, aggressive surgical therapy is recommended.
胃神经内分泌肿瘤（NET）较为罕见。临床上它们被分为1至3型。组织学分类依据世界卫生组织2000年内分泌肿瘤分类标准。1型NET与慢性萎缩性胃炎同时出现，为单个或多个小肿瘤。1型肿瘤预后极佳，随访期间未报告与肿瘤相关的死亡病例。2型NET是多发性内分泌腺瘤病1型（MEN - 1）综合征的一部分。这些肿瘤可能更具侵袭性，甚至会发生转移。然而，在大多数MEN - 1患者中，预后取决于该疾病的其他表现，如十二指肠或胰腺神经内分泌肿瘤。3型胃神经内分泌肿瘤是散发性肿瘤，与其他胃部病变无关。它们往往发病较早，无性别偏好。这些肿瘤可能发展为侵袭性病程，出现转移性疾病，总体预后较差。因此，建议采取积极的手术治疗。
