Knoepfler Paul S
Department of Cell Biology and Human Anatomy, Institute of Pediatric Regenerative Medicine, Shriners Hospital for Children Northern California, University of California Davis School of Medicine, Davis, California 95616, USA.
Cancer Res. 2007 Jun 1;67(11):5061-3. doi: 10.1158/0008-5472.CAN-07-0426.
Myc, a transcription factor commonly deregulated in tumorigenesis, is thought to mediate its diverse cellular effects by altering the expression of specific target genes. However, it has been difficult to gain a precise understanding of how Myc drives cancer because Myc acts rather weakly at many of its target loci, and it has been reported to regulate as many as 10% to 15% of all cellular genes. A new perspective on this issue has been provided by a recent study that revealed Myc can regulate chromatin structure in a global fashion. These findings suggest actions for Myc that extend beyond the traditional concept of a targeted gene regulator.
Myc是一种在肿瘤发生过程中普遍失调的转录因子，被认为通过改变特定靶基因的表达来介导其多样的细胞效应。然而，要精确理解Myc如何驱动癌症一直颇具难度，因为Myc在其许多靶位点的作用相当微弱，而且据报道它能调控多达10%至15%的所有细胞基因。最近一项研究为这个问题提供了新视角，该研究揭示Myc能以全局方式调控染色质结构。这些发现表明Myc的作用超出了传统的靶向基因调节因子概念。
