Osumi Michihiro, Sumitani Masahiko, Nobusako Satoshi, Sato Gosuke, Morioka Shu
Graduate School of Health Science, Kio University, Nara, Japan.
Neurorehabilitation Research Center, Kio University, Nara, Japan.
Scand J Pain. 2021 May 21;22(1):40-47. doi: 10.1515/sjpain-2021-0020. Print 2022 Jan 27.
Application of spatially interlaced innocuous warm and cool stimuli to the skin elicits illusory pain, known as the thermal grill illusion (TGI). This study aimed to discriminate the underlying mechanisms of central and peripheral neuropathic pain focusing on pain quality, which is considered to indicate the underlying mechanism(s) of pain. We compared pain qualities in central and peripheral neuropathic pain with reference to pain qualities of TGI-induced pain.
Experiment 1:137 healthy participants placed their hand on eight custom-built copper bars for 60 s and their pain quality was assessed by the McGill Pain Questionnaire. Experiment 2: Pain quality was evaluated in patients suffering from central and peripheral neuropathic pain (42 patients with spinal cord injury, 31 patients with stroke, 83 patients with trigeminal neuralgia and 131 patients with postherpetic neuralgia).
Experiment 1: Two components of TGI-induced pain were found using principal component analysis: component 1 included , , and , component 2 included , , , and . Experiment 2: Multiple correspondence analysis (MCA) and cross tabulation analysis revealed specific pain qualities including , , , , , and were associated with central neuropathic pain rather than peripheral neuropathic pain.
We found similar qualities between TGI-induced pain in healthy participants and central neuropathic pain rather than peripheral neuropathic pain. The mechanism of TGI is more similar to the mechanism of central neuropathic pain than that of neuropathic pain.
对皮肤施加空间交错的无害温热和冷刺激会引发幻痛，即热格栅错觉（TGI）。本研究旨在区分中枢性和外周性神经病理性疼痛的潜在机制，重点关注疼痛性质，其被认为可指示疼痛的潜在机制。我们参照TGI诱导疼痛的疼痛性质，比较了中枢性和外周性神经病理性疼痛的疼痛性质。
实验1：137名健康参与者将手放在八个定制的铜棒上60秒，并通过麦吉尔疼痛问卷评估其疼痛性质。实验2：对患有中枢性和外周性神经病理性疼痛的患者（42例脊髓损伤患者、31例中风患者、83例三叉神经痛患者和131例带状疱疹后神经痛患者）的疼痛性质进行评估。
实验1：使用主成分分析发现TGI诱导疼痛的两个成分：成分1包括 、 、 和 ，成分2包括 、 、 和 。实验2：多重对应分析（MCA）和交叉列表分析显示，特定的疼痛性质包括 、 、 、 、 和 与中枢性神经病理性疼痛相关，而非外周性神经病理性疼痛。
我们发现健康参与者中TGI诱导的疼痛与中枢性神经病理性疼痛而非外周性神经病理性疼痛具有相似的性质。TGI的机制与中枢性神经病理性疼痛的机制比与外周性神经病理性疼痛的机制更相似。
