非编码RNA对乳腺癌骨转移及转移抑制因子的调控

Regulation of bone metastasis and metastasis suppressors by non-coding RNAs in breast cancer.

作者信息

Sanjeev G, Pranavkrishna S, Akshaya R L, Rohini M, Selvamurugan N

机构信息

Department of Biotechnology, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, 603 103, Tamil Nadu, India.

出版信息

Biochimie. 2021 Aug;187:14-24. doi: 10.1016/j.biochi.2021.05.003. Epub 2021 May 18.

DOI:10.1016/j.biochi.2021.05.003

PMID:34019953

Abstract

Breast cancer (BC) is a critical health care issue that substantially affects women worldwide. Though surgery and chemotherapy can effectively control tumor growth, metastasis remains a primary concern. Metastatic BC cells predominantly colonize in bone, owing to their rigid osseous nutrient-rich nature. There are recently increasing studies investigating the context-dependent roles of non-coding RNAs (ncRNAs) in metastasis regulation. ncRNAs, including microRNAs, long non-coding RNAs, circular RNAs, and small interference RNAs, control the BC metastasis via altered mechanisms. Additionally, these ncRNAs have been reported in regulating a unique class of genes known as Metastatic suppressors. Metastasis suppressors like BRMS1, NM23, LIFR, and KAI1, etc., have been extensively studied for their role in inducing apoptosis, inhibiting metastasis, and maintaining homeostasis. In this review, we have emphasized the direct regulation of ncRNAs for effectively controlling the distant spread of BC. Furthermore, we have highlighted the ncRNA-mediated modulation of the metastatic suppressors, thereby delineating their indirect influence over metastasis.

摘要

乳腺癌（BC）是一个严重的医疗保健问题，对全球女性都有重大影响。尽管手术和化疗可以有效控制肿瘤生长，但转移仍然是主要关注点。转移性BC细胞主要定植于骨骼，这是由于骨骼具有坚硬且营养丰富的特性。最近有越来越多的研究探讨非编码RNA（ncRNAs）在转移调控中的背景依赖性作用。ncRNAs，包括微小RNA、长链非编码RNA、环状RNA和小干扰RNA，通过改变机制控制BC转移。此外，这些ncRNAs在调控一类独特的基因（称为转移抑制因子）方面也有报道。像BRMS1、NM23、LIFR和KAI1等转移抑制因子，因其在诱导凋亡、抑制转移和维持体内平衡中的作用而受到广泛研究。在本综述中，我们强调了ncRNAs对有效控制BC远处转移的直接调控作用。此外，我们突出了ncRNA介导的对转移抑制因子的调节作用，从而阐明它们对转移的间接影响。