维生素 D 与非编码 RNA：乳腺癌调控的新视角。

Vitamin D and Non-coding RNAs: New Insights into the Regulation of Breast Cancer.

机构信息

Department of Internal Medicine and endocrinology, Shohadae Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cancer Research Center, Shohada Tajrish Hospital, Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Curr Mol Med. 2021;21(3):194-210. doi: 10.2174/1566524020666200712182137.

DOI:10.2174/1566524020666200712182137

PMID:32652908

Abstract

Breast cancer, a life-threatening serious disease with a high incident rate among women, is responsible for thousands of cancer-associated death worldwide. Numerous investigations have evaluated the possible mechanisms related to this malignancy. Among them, non-coding RNAs (ncRNAs), i.e., microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs have recently attracted attention of researchers. In addition to recent studies for evaluating the role of ncRNAs in breast cancer etiology, some investigations have revealed that vitamin D has regulatory and therapeutic roles in breast cancer. Moreover, an important link between vitamin D and ncRNAs in cancer therapy has been highlighted. Herein, the aim of this study was to discuss the available data on the mentioned link in breast cancer.

摘要

乳腺癌是一种危及生命的严重疾病，女性发病率较高，是导致全球数千人癌症相关死亡的原因。大量研究评估了与这种恶性肿瘤相关的可能机制。其中，非编码 RNA（ncRNA），即 microRNAs（miRNAs）、长非编码 RNA（lncRNAs）和环状 RNA，最近引起了研究人员的关注。除了最近评估 ncRNA 在乳腺癌病因学中作用的研究外，一些研究还揭示了维生素 D 在乳腺癌中的调节和治疗作用。此外，还强调了维生素 D 和癌症治疗中 ncRNA 之间的重要联系。在此，本研究旨在讨论乳腺癌中所述联系的现有数据。