Pritchard Alexander O, Nemez Dion B, Herbert David E, Dakshinamurti Shyamala, Sorensen John L
Department of Chemistry, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.
Department of Physiology, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada.
Bioorg Med Chem Lett. 2021 Jul 15;44:128119. doi: 10.1016/j.bmcl.2021.128119. Epub 2021 May 19.
Forskolin (1) is a diterpene found in the Coleus forskohlii plant that has been examined for its medical properties resulting from adenylyl cyclase activation. This article describes a straightforward purification method of 1 from commercially available weight loss capsules. In addition, there has been some ambiguity with respect to the use of the name 'forskolin' to describe 1 and related diterpenes, which this report serves to eliminate. Herein we detail the complete spectroscopic characterization of purified 1 as well as its single crystal X-ray structure.
