The isolation, purification and complete characterization of the diterpene forskolin from nutritional supplements.
作者信息
Pritchard Alexander O, Nemez Dion B, Herbert David E, Dakshinamurti Shyamala, Sorensen John L
机构信息
Department of Chemistry, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.
Department of Physiology, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada.
出版信息
Bioorg Med Chem Lett. 2021 Jul 15;44:128119. doi: 10.1016/j.bmcl.2021.128119. Epub 2021 May 19.
Forskolin (1) is a diterpene found in the Coleus forskohlii plant that has been examined for its medical properties resulting from adenylyl cyclase activation. This article describes a straightforward purification method of 1 from commercially available weight loss capsules. In addition, there has been some ambiguity with respect to the use of the name 'forskolin' to describe 1 and related diterpenes, which this report serves to eliminate. Herein we detail the complete spectroscopic characterization of purified 1 as well as its single crystal X-ray structure.
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