Laboratory of Genetic Toxicology, Postgraduate Program in Molecular and Cell Biology Applied to Health, Lutheran University of Brazil (ULBRA), Avenida Farroupilha, 8001 Bairro São José, CEP 92425-900, Canoas, RS, Brazil.
Laboratory of Genetic Toxicology, Postgraduate Program in Molecular and Cell Biology Applied to Health, Lutheran University of Brazil (ULBRA), Avenida Farroupilha, 8001 Bairro São José, CEP 92425-900, Canoas, RS, Brazil.
Environ Pollut. 2021 Oct 15;287:117346. doi: 10.1016/j.envpol.2021.117346. Epub 2021 May 12.
Environmental exposure to pollution generated by mining and burning coal is inevitable for people living nearby. Therefore, the aim of this study was to evaluate the influence of coal dust on health conditions and genomic instability of individuals who live near coal mines and thermoelectric power plants, and to relate the results to inorganic elements and inflammatory responses. Thus, we evaluated 284 individuals from four cities in the south of Brazil around a region with coal mines and a thermoelectric power plant (one city was considered a negative control). The results of the Comet assay and Micronucleus (MN) test did not show a genotoxic or mutagenic effect related to environmental exposure to coal, but the inflammatory cytokine tumor necrosis factor-α (TNF-α) was increased in all cities around the power plant when compared to the control conditions. Higher levels of MN were associated with body mass index and cardiovascular risk, and higher levels of Damage Index (DI), TNF-α and interleukin1β (IL-1β) with number of cigarettes/day. Principal component analysis (PCA) was used to integrate DNA damage and inflammatory results with inorganic elements. This study also demonstrated the relationship between zinc and MN, copper, and interleukin10 (IL-10), and among silicon and sulfur with DI and nucleoplasmic bridge. A relationship was also observed between the reduction of inorganic elements and both aging and quality of health. The use of different methodologies and the relationship between the results obtained in these studies, including different lifestyles, can increase the understanding of the interaction between this mineral and the health status of residents of regions affected by coal pollution.
人们生活在附近，不可避免地会受到采矿和燃煤产生的污染的环境暴露。因此，本研究旨在评估生活在煤矿和火力发电站附近的个体所受到的煤尘对健康状况和基因组不稳定性的影响，并将结果与无机元素和炎症反应联系起来。因此，我们评估了来自巴西南部四个城市的 284 个人，这些城市位于一个有煤矿和火力发电厂的地区（一个城市被认为是阴性对照）。彗星试验和微核（MN）试验的结果并未显示与环境暴露于煤有关的遗传毒性或致突变作用，但与对照条件相比，所有靠近电厂的城市的炎症细胞因子肿瘤坏死因子-α（TNF-α）均增加。较高的 MN 水平与体重指数和心血管风险有关，而较高的损伤指数（DI）、TNF-α 和白细胞介素 1β（IL-1β）水平与每天吸烟的数量有关。主成分分析（PCA）用于将 DNA 损伤和炎症结果与无机元素整合在一起。本研究还证明了锌与 MN、铜和白细胞介素 10（IL-10）之间的关系，以及硅和硫与 DI 和核质桥之间的关系。还观察到无机元素的减少与衰老和健康质量之间存在关系。不同方法的使用以及这些研究中获得的结果之间的关系，包括不同的生活方式，可以增加对这种矿物质与受煤污染地区居民健康状况之间相互作用的理解。
