Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Radboud University Medical Center, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands.
UFR Biosciences, Université Félix Houghouët-Boigny, 01 BP V34 Abidjan, Côte d'Ivoire.
Psychoneuroendocrinology. 2021 Jul;129:105255. doi: 10.1016/j.psyneuen.2021.105255. Epub 2021 May 12.
This semi-randomized controlled trial examined the effects of a probiotic food supplement on cortisol and C-reactive protein (CRP) in a sample of 262 four-to seven-year-old children (56% girls) in two economically-disadvantaged schools in an urban setting in Côte d'Ivoire. For one semester, children in one school were randomized to receive a probiotic (N = 79) or placebo (N = 85) fermented dairy food each day they attended school; one child (due to medical reasons) and all children in the other school (N = 98) continued their diets as usual. Children provided two saliva samples at 11:30 on consecutive days at the end of the study. Analyses revealed that the probiotic group had lower cortisol than the placebo or diet-as-usual groups (p = .015); CRP levels were comparable across groups (p = .549). Exploratory analyses suggested that dose and regularity of consumption may impact the biomarkers as well. This study provides the first evidence that a probiotic milk product may lower cortisol in a sample of young, economically-disadvantaged children.
本半随机对照试验研究了益生菌食品补充剂对科特迪瓦城市经济困难地区两所学校 262 名 4 至 7 岁儿童（56%为女孩）皮质醇和 C 反应蛋白（CRP）的影响。在一个学期中，一所学校的儿童随机分为益生菌组（N=79）或安慰剂组（N=85），每天上学时食用发酵乳制品；另一所学校的一名儿童（因医疗原因）和所有儿童（N=98）继续按常规饮食。研究结束时，儿童在连续两天的 11:30 提供了两份唾液样本。分析显示，益生菌组的皮质醇低于安慰剂组或常规饮食组（p=0.015）；各组 CRP 水平相当（p=0.549）。探索性分析表明，剂量和消费规律也可能影响生物标志物。本研究首次提供了证据表明，益生菌牛奶产品可能降低经济困难的年轻儿童的皮质醇水平。
