Department of Medical Oncology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
Department of Internal Medicine, Martini Hospital Groningen, Groningen, the Netherlands.
Breast. 2021 Aug;58:138-146. doi: 10.1016/j.breast.2021.05.004. Epub 2021 May 15.
Adjuvant endocrine therapy (ET) in patients with breast cancer (BC) increases the risk of becoming less physically active. Physical inactivity is associated with a higher risk of treatment-related side effects and mortality. This study investigated whether supervised exercise increased the proportion of patients adhering to the national physical activity (PA) guideline during adjuvant ET in overweight or obese BC patients.
This multicentre single-arm clinical trial included patients with BC participating in a 12-week supervised exercise intervention. An accelerometer measured moderate to vigorous PA (MVPA) at baseline (T0), after 12 (T1) and 26 weeks (T2). The primary endpoint was change in the proportion of patients with weekly ≥150 min of MVPA at T1 compared to T0. Secondary endpoints were adherence to PA guideline at T2, metabolic syndrome (MetS), body composition, health-related quality of life (HRQoL) and BC-specific functioning and symptoms, self-reported PA, self-efficacy, exercise motivation and satisfaction with life.
141 patients with a median age of 61 years and a mean BMI of 31.3 participated. Adherence to the PA guideline increased from 38.3% at T0, to 40.4% at T1 (p = .112) and 44.7% at T2 (p = .003). MetS, body composition, HRQoL, BC-specific functioning and symptoms (i.e. fatigue, dyspnoea), self-reported PA, self-efficacy, exercise motivation and satisfaction with life improved significantly over time.
Supervised exercise increased the proportion of BC patients adhering to the PA guideline over time. Furthermore, MetS, body composition, HRQoL and symptoms improved. Our findings highlight the clinical relevance of supervised exercise during ET in overweight BC patients.
(NCT02424292).
乳腺癌（BC）患者接受辅助内分泌治疗（ET）会增加身体活动减少的风险。身体活动不足与治疗相关副作用和死亡率升高相关。本研究旨在探讨监督下的运动是否能增加超重或肥胖 BC 患者接受辅助 ET 期间遵守国家体力活动（PA）指南的患者比例。
这是一项多中心、单臂临床试验，纳入了参加为期 12 周监督运动干预的 BC 患者。基线（T0）、12 周（T1）和 26 周（T2）时使用加速度计测量中等至剧烈体力活动（MVPA）。主要终点是 T1 时每周有≥150 分钟 MVPA 的患者比例与 T0 相比的变化。次要终点是 T2 时对 PA 指南的依从性、代谢综合征（MetS）、身体成分、健康相关生活质量（HRQoL）和 BC 特异性功能和症状、自我报告的 PA、自我效能、运动动机和生活满意度。
141 名中位年龄为 61 岁、平均 BMI 为 31.3 的患者参与了研究。PA 指南的依从性从 T0 时的 38.3%增加到 T1 时的 40.4%（p=.112）和 T2 时的 44.7%（p=.003）。MetS、身体成分、HRQoL、BC 特异性功能和症状（即疲劳、呼吸困难）、自我报告的 PA、自我效能、运动动机和生活满意度随时间显著改善。
监督下的运动随时间推移增加了 BC 患者遵守 PA 指南的比例。此外，MetS、身体成分、HRQoL 和症状得到改善。我们的研究结果强调了超重 BC 患者接受 ET 期间监督下运动的临床相关性。
（NCT02424292）。
