Travier Noemie, Guillamo Elisabeth, Oviedo Guillermo R, Valls Joan, Buckland Genevieve, Fonseca-Nunes Ana, Alamo Juan M, Arribas Lorena, Moreno Ferran, Sanz Tania E, Borras Josep M, Agudo Antonio, Javierre Casimiro
a Unit of Nutrition, Environment and Cancer , Catalan Institute of Oncology (ICO-IDIBELL) , Barcelona , Spain.
Women Health. 2015;55(5):505-24. doi: 10.1080/03630242.2015.1022817. Epub 2015 Apr 2.
This study assessed changes in quality of life (QoL) and cardiorespiratory fitness (CRF) during a diet and physical activity (PA) intervention in breast cancer (BC) survivors and investigated the relation between these changes. The intervention of this single-arm pre-post study involved supervised, 1-hour weekly, diet sessions and 75-minute bi-weekly PA sessions of moderate-to-high intensity. This 12-week intervention targeted overweight/obese women who had recently completed BC treatment. Pre- and post-CRF and QoL measurements were compared using paired t-tests. Linear regression models, including baseline participants' characteristics and weight change, were used to assess the association between changes in CRF and QoL. The 37 BC survivors who completed the intervention between May 7, 2012 and July 27, 2012 showed significant increases in CRF and QoL. Peak oxygen uptake (mL/kg/min) increased from 19.0 ± 2.8 to 24.0 ± 4.1 while peak workload (watts/kg) increased from 1.3 ± 0.3 to 1.7 ± 0.3. Although statistical significance was not reached, the increase in workload seemed associated with increases in physical, mental, and general health and with a decrease in fatigue. This lifestyle intervention improved BC survivors' QoL and CRF and suggested possible relationships between CRF and QoL. More research needs to confirm these associations and promote lifestyle interventions aiming at improving BC survivors' QoL.
本研究评估了乳腺癌（BC）幸存者在饮食和身体活动（PA）干预期间生活质量（QoL）和心肺适能（CRF）的变化，并调查了这些变化之间的关系。这项单组前后对照研究的干预措施包括每周1小时、有监督的饮食课程，以及每两周一次、时长75分钟的中高强度PA课程。这项为期12周的干预针对的是近期完成BC治疗的超重/肥胖女性。使用配对t检验比较CRF和QoL的前后测量值。线性回归模型，包括基线参与者的特征和体重变化，用于评估CRF变化与QoL之间的关联。在2012年5月7日至2012年7月27日期间完成干预的37名BC幸存者的CRF和QoL有显著提高。峰值摄氧量（毫升/千克/分钟）从19.0±2.8增加到24.0±4.1，而峰值工作量（瓦特/千克）从1.3±0.3增加到1.7±0.3。虽然未达到统计学显著性，但工作量的增加似乎与身体、心理和总体健康状况的改善以及疲劳感的降低有关。这种生活方式干预改善了BC幸存者的QoL和CRF，并表明了CRF与QoL之间可能存在的关系。需要更多研究来证实这些关联，并推广旨在改善BC幸存者QoL的生活方式干预措施。
