Pycock C J, Marsden C D
Eur J Pharmacol. 1978 Jan 15;47(2):167-75. doi: 10.1016/0014-2999(78)90388-6.
The hypothesis that the rotating rat requires both nigro-striatal and mesolimbic dopaminergic components for activity has been tested. 6-Hydroxydopamine lesions were induced unilaterally in either or both the ascending nigrostriatal and mesolimbic dopamine pathway. In one group of rats the nucleus accumbens was destroyed bilaterally with electrolesions. Circling behaviour was only recorded when there was both an imbalance in striatal dopamine concentrations concomitant with stimulation of the limbic dopamine regions. Lesions of the mesolimbic dopamine pathway resulted in changes in drug-induced motor activity but postural asymmetry or circling behaviour was not observed. The results support the hypothesis that the rotating rodent requires two functional dopamine components: striatal dopamine imbalance causing a postural asymmetry and stimulation of mesolimbic dopamine systems providing a locomotor component. The relevance of these components in this animal model is discussed with reference to dopaminergic agonist and antagonist drugs.
旋转大鼠的活动需要黑质纹状体和中脑边缘多巴胺能成分这一假说已得到验证。在单侧或双侧的黑质纹状体和中脑边缘多巴胺上行通路中诱导产生6-羟基多巴胺损伤。在一组大鼠中，用电损伤双侧损毁伏隔核。仅当纹状体多巴胺浓度失衡并伴有边缘多巴胺区域受刺激时，才记录到转圈行为。中脑边缘多巴胺通路损伤导致药物诱导的运动活动发生变化，但未观察到姿势不对称或转圈行为。结果支持了这一假说，即旋转啮齿动物需要两种功能性多巴胺成分：纹状体多巴胺失衡导致姿势不对称，中脑边缘多巴胺系统受刺激提供运动成分。并参考多巴胺能激动剂和拮抗剂药物讨论了这些成分在该动物模型中的相关性。
