Division of Food and Nutrition, Graduate School of Human Sciences and Design, Japan Women's University.
Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women's University.
J Atheroscler Thromb. 2022 Jun 1;29(6):881-893. doi: 10.5551/jat.62832. Epub 2021 May 22.
Improving cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) has been regarded as a novel target for preventing cardiovascular disease. HDL reportedly has antioxidant properties which may contribute to its functions. We investigated changes in CEC with intake of the Japan Diet (JD) recommended by the Japan Atherosclerosis Society and the relationship of these changes to serum antioxidant concentrations.
A randomized parallel controlled clinical trial on JD intake was performed in Japanese patients with dyslipidemia. Ninety-eight participants were randomly divided into the JD (n=49) or the partial JD (PJD) (n=49) group. Nutrition education, based on each diet at baseline and at 3 months, was provided and the participants were followed up for 6 months.
Mean CEC was 1.05 in total and correlated positively with HDL-cholesterol (p＜0.001) at baseline. CEC did not change while oxygen radical absorbance capacity (ORAC) was decreased in both groups (p＜0.001). Although serum total carotenoid increased in both groups, serum α-tocopherol decreased in the JD group as compared to the PJD group (p＜0.05). CEC correlated positively with HDL ORAC at baseline (p=0.021) and with serum total carotenoid at 3 and 6 months (p=0.005, 0.035). Changes in CEC correlated positively with changes in HDL ORAC at 3 months and serum total tocopherol at 3 and 6 months (p＜0.001).
CEC was not changed by JD education in Japanese patients with dyslipidemia who already had normal CEC at baseline. CEC was suggested to be positively associated with serum α- and γ-tocopherol and HDL ORAC.
提高高密度脂蛋白（HDL）的胆固醇外排能力（CEC）已被视为预防心血管疾病的新靶点。据报道，HDL 具有抗氧化特性，这可能与其功能有关。我们研究了摄入日本动脉硬化学会推荐的日本饮食（JD）后 CEC 的变化，以及这些变化与血清抗氧化剂浓度的关系。
在日本血脂异常患者中进行了一项关于 JD 摄入的随机平行对照临床试验。98 名参与者被随机分为 JD（n=49）或部分 JD（PJD）（n=49）组。在基线和 3 个月时，根据每种饮食对参与者进行营养教育，并随访 6 个月。
总 CEC 平均值为 1.05，与基线时的 HDL-胆固醇呈正相关（p＜0.001）。在两组中，CEC 没有变化，而氧自由基吸收能力（ORAC）均降低（p＜0.001）。虽然两组血清总类胡萝卜素均增加，但 JD 组血清α-生育酚较 PJD 组下降（p＜0.05）。CEC 与基线时的 HDL-ORAC 呈正相关（p=0.021），与 3 个月和 6 个月时的血清总类胡萝卜素呈正相关（p=0.005，0.035）。CEC 的变化与 3 个月时 HDL-ORAC 的变化以及 3 个月和 6 个月时血清总生育酚的变化呈正相关（p＜0.001）。
在基线时 CEC 已经正常的血脂异常日本患者中，JD 教育并没有改变 CEC。CEC 与血清α-和γ-生育酚和 HDL-ORAC 呈正相关。
