School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, China; Guangdong Engineering Technology Center of Nutrition Transformation, Guangzhou, China; Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, China; Guangdong Engineering Technology Center of Nutrition Transformation, Guangzhou, China.
Nutrition. 2022 Sep;101:111703. doi: 10.1016/j.nut.2022.111703. Epub 2022 Apr 22.
Coenzyme Q10 (CoQ10) had shown promising effects in improving the lipid and glycemic profile in dyslipidemic individuals in our previous work, but little is known about how it affects high-density lipoprotein (HDL) function in patients with dyslipidemia. The aim of this study was to explore the effects of CoQ10 supplementation on HDL function in people with dyslipidemia.
A 24-wk, randomized, double-blind, placebo-controlled trial was conducted in 101 people with dyslipidemia. All patients were randomized into the CoQ10 group (120 mg/d, n = 51) or the placebo group (n = 50). High-density lipoprotein-mediated cholesterol efflux capacity (CEC), HDL inflammatory index (HII), and HDL intrinsic oxidation were measured at baseline, 12 wk, and 24 wk.
CoQ10 supplementation for 24 wk significantly improved HDL-mediated CEC (mean change, 1.21±2.44 versus -0.12±2.94; P = 0.014) and reduced HII (mean change, -0.32±0.58 versus -0.05±0.49, P = 0.014) compared with placebo. However, there was no significant difference in the effect of CoQ10 on HDL intrinsic oxidation between the two groups after 24 wk (P = 0.290). A positive correlation was found between the changes in CEC and HDL cholesterol in the CoQ10 group (r, 0.30; P = 0.032). Furthermore, we also found that the improved HDL functions were more obvious in elderly, female, or non-obese individuals, which indicated a specific population that benefits most from CoQ10 intervention.
This study suggested that supplementation of CoQ10 for 24 wk can significantly improve HDL-mediated CEC and antiinflammatory function of HDL in patients with dyslipidemia.
辅酶 Q10（CoQ10）在我们之前的研究中已显示出改善血脂异常个体的脂质和血糖谱的良好效果，但对于其如何影响血脂异常患者的高密度脂蛋白（HDL）功能知之甚少。本研究旨在探讨 CoQ10 补充对血脂异常患者 HDL 功能的影响。
对 101 名血脂异常患者进行了 24 周、随机、双盲、安慰剂对照试验。所有患者均随机分为 CoQ10 组（120mg/d，n=51）或安慰剂组（n=50）。在基线、12 周和 24 周时测量高密度脂蛋白介导的胆固醇流出能力（CEC）、HDL 炎症指数（HII）和 HDL 内在氧化。
CoQ10 补充 24 周可显著改善 HDL 介导的 CEC（平均变化，1.21±2.44 与-0.12±2.94；P=0.014）和降低 HII（平均变化，-0.32±0.58 与-0.05±0.49，P=0.014），与安慰剂相比。然而，两组间 CoQ10 对 HDL 内在氧化的影响在 24 周后无显著差异（P=0.290）。CoQ10 组中 CEC 的变化与 HDL 胆固醇之间存在正相关（r，0.30；P=0.032）。此外，我们还发现 CoQ10 干预后，HDL 功能的改善在老年、女性或非肥胖个体中更为明显，这表明特定人群从 CoQ10 干预中获益最大。
本研究表明，CoQ10 补充 24 周可显著改善血脂异常患者的 HDL 介导的 CEC 和 HDL 的抗炎功能。
