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他汀类药物相关坏死性自身免疫性肌病合并重症肌无力

Statin-associated necrotizing autoimmune myopathy with concurrent myasthenia gravis.

作者信息

Frasson Emma, Simonetto Marco, Bertolasi Laura, Caneve Giorgio, Vilotti Cristina, Ruzza Giampietro, Perelli Anna, Piccinno Maria Grazia, Monaco Salvatore

机构信息

Department of Neurology AULSS 6 Euganea Cittadella Hospital Padua Italy.

Section of Clinical Neurology Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy.

出版信息

Clin Case Rep. 2021 Mar 28;9(5):e03925. doi: 10.1002/ccr3.3925. eCollection 2021 May.

DOI:10.1002/ccr3.3925
PMID:34026125
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8117815/
Abstract

Statin treatment has been associated with necrotizing autoimmune myopathy and has been linked to myasthenia gravis. We present an unprecedented clinical challenge with both disorders occurring in a patient treated with statins few months earlier.

摘要

他汀类药物治疗与坏死性自身免疫性肌病有关，也与重症肌无力有关。我们呈现了一个前所未有的临床挑战，即这两种疾病在一名数月前接受他汀类药物治疗的患者身上同时出现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f171/8117815/260ab65501ec/CCR3-9-e03925-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f171/8117815/260ab65501ec/CCR3-9-e03925-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f171/8117815/260ab65501ec/CCR3-9-e03925-g002.jpg

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本文引用的文献

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Statins and autoimmunity: State-of-the-art.他汀类药物与自身免疫：最新进展。
Pharmacol Ther. 2020 Oct;214:107614. doi: 10.1016/j.pharmthera.2020.107614. Epub 2020 Jun 24.
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Clinical spectrums and outcomes of necrotizing autoimmune myopathy versus other idiopathic inflammatory myopathies: a multicenter case-control study.坏死性自身免疫性肌病与其他特发性炎性肌病的临床谱和结局：一项多中心病例对照研究。
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他汀类药物的使用与新冠病毒病及其他呼吸道感染的关系：肌肉及其他考量因素
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Anti-HMGCR Myopathy.抗 HMGCR 肌病。
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224th ENMC International Workshop:: Clinico-sero-pathological classification of immune-mediated necrotizing myopathies Zandvoort, The Netherlands, 14-16 October 2016.第224届ENMC国际研讨会：免疫介导性坏死性肌病的临床-血清学-病理学分类，荷兰赞德福特，2016年10月14日至16日。
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Myotoxicity of statins: Mechanism of action.他汀类药物的肌毒性：作用机制。
Pharmacol Ther. 2017 Jul;175:1-16. doi: 10.1016/j.pharmthera.2017.02.029. Epub 2017 Feb 14.
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Clinical features and prognosis in anti-SRP and anti-HMGCR necrotising myopathy.抗信号识别颗粒和抗 3-羟基-3-甲基戊二酰辅酶 A 还原酶肌炎的临床特征和预后。
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Statins and Myasthenia Gravis.他汀类药物与重症肌无力
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Statin-Associated Autoimmune Myopathy.他汀类药物相关自身免疫性肌病
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Immune-mediated statin myopathy.免疫介导的他汀类药物性肌病。
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