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β-榄香烯通过增强表达降低非小细胞肺癌的恶性程度。

Beta-Elemene Reduces the Malignancy of Non-Small Cell Lung Cancer by Enhancing Expression.

作者信息

Cai Hu, Ren Lili, Wang Ying, Zhang Yongjun

机构信息

Department of Integration of Traditional Chinese and Western Medicine, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, China.

Department of Gynecological Oncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, China.

出版信息

Front Oncol. 2021 May 7;11:571476. doi: 10.3389/fonc.2021.571476. eCollection 2021.

DOI:10.3389/fonc.2021.571476
PMID:34026596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8137837/
Abstract

BACKGROUND

Beta-elemene has potent anti-tumor effect, but its anti-tumor mechanism remains unclear. Chromosome 3 open reading frame 21 (C3orf21) acts as a tumor suppressor. This study tested whether the anti-tumor effect of beta-elemene was associated with modulating C3orf21 expression in non-small cell lung cancer (NSCLC).

MATERIALS AND METHODS

The impact of beta-elemene on C3orf21 expression in NSCLC cells was quantified. The stable C3orf21 silencing A549 and over-expressing PC-9 cells were established and their effects on the beta-elemene-attenuated proliferation, wound healing and invasion of NSCLC cells as well as the expression of key regulators and signal events were determined.

RESULTS

Beta-elemene significantly up-regulated C3orf21 expression in NSCLC cells. Beta-elemene treatment significantly attenuated the proliferation, wound healing and invasion of NSCLC cells, which were significantly mitigated by C3orf21 silencing, but enhanced by C3orf21 over-expression. Similar patterns of beta-elemene-modulated cyclinD1, c-Myc, COX2, MMP2, MMP9, VEGF, PTEN and Notch1 expression were detected in NSCLC cells.

CONCLUSIONS

Such data indicated that beta-elemene treatment attenuated the malignancy of NSCLC cells by up-regulating C3orf21 expression. Our findings may provide new mechanisms underlying the pharmacological action of beta-elemene.

摘要

背景

β-榄香烯具有强大的抗肿瘤作用，但其抗肿瘤机制仍不清楚。3号染色体开放阅读框21（C3orf21）作为一种肿瘤抑制因子。本研究检测β-榄香烯的抗肿瘤作用是否与调节非小细胞肺癌（NSCLC）中C3orf21的表达有关。

材料与方法

对β-榄香烯对NSCLC细胞中C3orf21表达的影响进行定量分析。构建稳定沉默C3orf21的A549细胞和过表达C3orf21的PC-9细胞，并确定它们对β-榄香烯减弱NSCLC细胞增殖、伤口愈合和侵袭的影响，以及关键调节因子和信号事件的表达。

结果

β-榄香烯显著上调NSCLC细胞中C3orf21的表达。β-榄香烯处理显著减弱NSCLC细胞的增殖、伤口愈合和侵袭，C3orf21沉默可显著减轻这些作用，而C3orf21过表达则增强这些作用。在NSCLC细胞中检测到β-榄香烯调节细胞周期蛋白D1、c-Myc、COX2、MMP2、MMP9、VEGF、PTEN和Notch1表达的类似模式。

结论

这些数据表明，β-榄香烯处理通过上调C3orf21表达减弱NSCLC细胞的恶性程度。我们的研究结果可能为β-榄香烯的药理作用提供新的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/8eb36e136f4b/fonc-11-571476-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/276c8199968c/fonc-11-571476-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/3d6a0cba75e9/fonc-11-571476-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/cb8531448cd5/fonc-11-571476-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/76d7f38dd41b/fonc-11-571476-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/6c2ecd0ae9a4/fonc-11-571476-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/cfa45d6b5a33/fonc-11-571476-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/75e0e7b7fdf8/fonc-11-571476-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/8eb36e136f4b/fonc-11-571476-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/276c8199968c/fonc-11-571476-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/3d6a0cba75e9/fonc-11-571476-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/cb8531448cd5/fonc-11-571476-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/76d7f38dd41b/fonc-11-571476-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/6c2ecd0ae9a4/fonc-11-571476-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/cfa45d6b5a33/fonc-11-571476-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/75e0e7b7fdf8/fonc-11-571476-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a04/8137837/8eb36e136f4b/fonc-11-571476-g008.jpg

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