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N Engl J Med. 2018 Nov 29;379(22):2091-2093. doi: 10.1056/NEJMp1809643.
2
Assessing Drug Safety in Children - The Role of Real-World Data.评估儿童用药安全性——真实世界数据的作用。
N Engl J Med. 2018 Jun 7;378(23):2155-2157. doi: 10.1056/NEJMp1802197.
3
ClearTK 2.0: Design Patterns for Machine Learning in UIMA.ClearTK 2.0:UIMA中机器学习的设计模式
LREC Int Conf Lang Resour Eval. 2014 May;2014:3289-3293.
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MIMIC-III, a freely accessible critical care database.MIMIC-III,一个免费获取的重症监护数据库。
Sci Data. 2016 May 24;3:160035. doi: 10.1038/sdata.2016.35.
5
Clinical and economic burden of adverse drug reactions.药物不良反应的临床和经济负担。
J Pharmacol Pharmacother. 2013 Dec;4(Suppl 1):S73-7. doi: 10.4103/0976-500X.120957.
6
A comparison of results of the US food and drug administration's mini-sentinel program with randomized clinical trials: the case of gastrointestinal tract bleeding with dabigatran.美国食品药品监督管理局微型哨点计划结果与随机临床试验的比较:达比加群所致胃肠道出血的案例
JAMA Intern Med. 2014 Jan;174(1):150-1. doi: 10.1001/jamainternmed.2013.12217.
7
Discovering body site and severity modifiers in clinical texts.发现临床文本中的身体部位和严重程度修饰语。
J Am Med Inform Assoc. 2014 May-Jun;21(3):448-54. doi: 10.1136/amiajnl-2013-001766. Epub 2013 Oct 3.
8
Food and Drug Administration (FDA) postmarket reported side effects and adverse events associated with pulmonary hypertension therapy in pediatric patients.美国食品药品监督管理局(FDA)发布了儿科患者肺动脉高压治疗相关的上市后报告的副作用和不良事件。
Pediatr Cardiol. 2013 Oct;34(7):1628-36. doi: 10.1007/s00246-013-0688-2. Epub 2013 Mar 27.
9
Drug safety surveillance using de-identified EMR and claims data: issues and challenges.利用去标识化的电子病历和理赔数据进行药物安全监测:问题与挑战。
J Am Med Inform Assoc. 2010 Nov-Dec;17(6):671-4. doi: 10.1136/jamia.2010.008607.
10
Mayo clinical Text Analysis and Knowledge Extraction System (cTAKES): architecture, component evaluation and applications.梅奥临床文本分析和知识提取系统(cTAKES):架构、组件评估和应用。
J Am Med Inform Assoc. 2010 Sep-Oct;17(5):507-13. doi: 10.1136/jamia.2009.001560.

以最少的工程投入提取药品不良事件信息。

Extracting Adverse Drug Event Information with Minimal Engineering.

作者信息

Miller Timothy, Geva Alon, Dligach Dmitriy

机构信息

Computational Health Informatics Program, Boston Children's Hospital.

Harvard Medical School.

出版信息

Proc Conf. 2019 Jun;2019:22-27. doi: 10.18653/v1/w19-1903.

DOI:10.18653/v1/w19-1903
PMID:34027520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8140592/
Abstract

In this paper we describe an evaluation of the potential of classical information extraction methods to extract drug-related attributes, including adverse drug events, and compare to more recently developed neural methods. We use the 2018 N2C2 shared task data as our gold standard data set for training. We train support vector machine classifiers to detect drug and drug attribute spans, and pair these detected entities as training instances for an SVM relation classifier, with both systems using standard features. We compare to baseline neural methods that use standard contextualized embedding representations for entity and relation extraction. The SVM-based system and a neural system obtain comparable results, with the SVM system doing better on concepts and the neural system performing better on relation extraction tasks. The neural system obtains surprisingly strong results compared to the system based on years of research in developing features for information extraction.

摘要

在本文中,我们描述了对经典信息提取方法提取药物相关属性(包括药物不良事件)潜力的评估,并与最近开发的神经方法进行比较。我们使用2018年N2C2共享任务数据作为训练的黄金标准数据集。我们训练支持向量机分类器来检测药物和药物属性跨度,并将这些检测到的实体配对作为支持向量机关系分类器的训练实例,两个系统均使用标准特征。我们与使用标准上下文嵌入表示进行实体和关系提取的基线神经方法进行比较。基于支持向量机的系统和神经系统获得了可比的结果,支持向量机系统在概念方面表现更好,而神经系统在关系提取任务方面表现更好。与基于多年信息提取特征开发研究的系统相比,神经系统获得了惊人的强大结果。