School of basic medical Sciences, Zhengzhou University, Zhengzhou, China.
School of Public Health, Zhengzhou University, Zhengzhou, China.
Andrologia. 2021 Aug;53(7):e14099. doi: 10.1111/and.14099. Epub 2021 May 24.
Whether obesity affects the quality of semen has become the focus of research. However, there are some deficiencies in the past research, because the vast majority of known infertile patients were included in the study samples. Taking infertile men as the research object to analyse the impact of obesity on semen quality, which cannot accurately prove that the impact on semen quality is caused by obesity, because the impact on semen quality may also be caused by other factors. Therefore, we selected ordinary obese men rather than infertile patients to conduct a systematic review and meta-analysis of the effects of obesity on semen parameters. The results showed that obesity had no effect on sperm concentration (SMD: -0.15, 95% CI: -0.32 ~ 0.02, p = .088) and percentage of normal sperm morphology (SMD: -0.17, 95% CI: -0.66 ~ 0.32, p = .487), but decreased semen volume (SMD: -0.32, 95% CI: -0.52 ~ -0.12, p = .002), total sperm number (SMD: -0.77, 95% CI: -1.31 ~ -0.23, p = .005), percentage of forward progression (SMD: -0.95, 95% CI: -1.7 ~ -0.19, p = .014) and percentage of viability (SMD: -0.812, 95% CI: -1.532 ~ -0.093, p = .027). Therefore, obesity affects semen quality to a certain extent, and maintaining normal weight may be one of the effective ways to improve male fertility.
肥胖是否影响精液质量已成为研究焦点。然而，过去的研究存在一些缺陷，因为绝大多数已知的不育患者都包含在研究样本中。以不育男性为研究对象，分析肥胖对精液质量的影响，并不能准确证明对精液质量的影响是由肥胖引起的，因为对精液质量的影响也可能由其他因素引起。因此，我们选择普通肥胖男性而不是不育患者，对肥胖对精液参数的影响进行了系统评价和荟萃分析。结果表明，肥胖对精子浓度（SMD：-0.15，95%CI：-0.320.02，p=0.088）和正常精子形态百分比（SMD：-0.17，95%CI：-0.660.32，p=0.487）无影响，但降低了精液量（SMD：-0.32，95%CI：-0.52-0.12，p=0.002）、总精子数（SMD：-0.77，95%CI：-1.31-0.23，p=0.005）、前向运动精子百分比（SMD：-0.95，95%CI：-1.7-0.19，p=0.014）和活力百分比（SMD：-0.812，95%CI：-1.532-0.093，p=0.027）。因此，肥胖在一定程度上影响精液质量，保持正常体重可能是提高男性生育能力的有效方法之一。
