Deptartments of Public Health & Community Medicine, Pediatrics, and Ophthalmology, Tufts University School of Medicine, Boston, USA.
Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany.
Acta Paediatr. 2021 Sep;110(9):2521-2528. doi: 10.1111/apa.15945. Epub 2021 Jun 6.
To explore the current literature on prenatal inflammation-associated risk factors for retinopathy of prematurity (ROP).
Subjective summary of selected experimental and epidemiological publications that support the authors' central hypothesis that the aetiology of ROP begins before birth.
Based on current evidence we suggest that, contrary to current aetiological models, the process of ROP development begins with a prephase in utero. This beginning is likely initiated by inflammatory responses that are associated with intrauterine infection.
We propose a novel aetio-pathogenetic model of ROP and suggest that the effects of postnatal exposure to inflammatory stressors (resulting from infection or hyperoxia or both) as well as those of other pre- and postnatal contributors to the complex pathogenesis of ROP might be modified by the prenatal phase of the disease.
探讨与早产儿视网膜病变（ROP）相关的产前炎症相关危险因素的现有文献。
对支持作者中心假设的选定实验和流行病学出版物进行主观总结，该假设认为 ROP 的病因始于出生前。
基于目前的证据，我们建议与当前的病因模型相反，ROP 发展的过程从子宫内的前相开始。这一开端可能是由与宫内感染相关的炎症反应引起的。
我们提出了 ROP 的一种新的病因发病模型，并建议，与 ROP 复杂发病机制相关的其他产前和产后因素一样，出生后暴露于炎症应激源（由感染或高氧或两者共同引起）的影响可能会被疾病的产前阶段所改变。
