Wu Hui, Zhang Juan, Zhang Jing, Yu Yanhong, Zhang Hua, Han Tongyan
Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China.
Children (Basel). 2025 Apr 15;12(4):509. doi: 10.3390/children12040509.
: Bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) affect the prognosis of preterm infants, and their coexistence is a risk factor for poor long-term outcomes in very low-birth-weight infants. However, there has been limited in-depth assessment of common and independent risk factors for BPD and ROP within the same cohort. Therefore, we aimed to investigate the risk factors for BPD and ROP in very low-birth-weight infants born at ≤32 weeks of gestation and to explore the interaction between these two diseases. : The participants were divided into four groups: BPD+ROP+, BPD-ROP-, BPD+ROP-, and BPD-ROP+. Gestational age, birth weight, maternal pregnancy complications, birth and postnatal diseases, and treatment conditions were compared among the groups. Subsequently, univariate and multivariate binary logistic regression analyses were conducted to explore the independent risk factors for BPD and ROP. : Common risk factors of BPD and ROP included gestational age and prolonged oxygen therapy. The multivariate analysis revealed that gestational age (OR: 4.44; 95% CI: 3-6.57), intubation resuscitation (OR: 2.35; 95% CI: 1.09-5.05), mechanical ventilation duration ≥ 7 days (OR: 1.01; 95% CI: 1.01-1.01), and prolonged total oxygen therapy (OR: 3.13; 95% CI: 1.28-7.64) were independent risk factors for BPD. Additionally, gestational age (OR: 0.66; 95% CI: 0.54-0.81) and prolonged oxygen therapy (OR: 1.02; 95% CI: 1-1.03) were independent risk factors for ROP. : The proper control of the duration and concentration of oxygen therapy, along with the minimization of mechanical ventilation time, is crucial for reducing the incidence of both BPD and ROP.
支气管肺发育不良（BPD）和早产儿视网膜病变（ROP）影响早产儿的预后，二者并存是极低出生体重儿长期预后不良的一个危险因素。然而，在同一队列中，对BPD和ROP的共同及独立危险因素进行的深入评估有限。因此，我们旨在调查孕周≤32周的极低出生体重儿发生BPD和ROP的危险因素，并探讨这两种疾病之间的相互作用。：参与者被分为四组：BPD+ROP+、BPD-ROP-、BPD+ROP-和BPD-ROP+。对各组之间的孕周、出生体重、母亲妊娠并发症、出生及产后疾病和治疗情况进行比较。随后，进行单因素和多因素二元逻辑回归分析，以探讨BPD和ROP的独立危险因素。：BPD和ROP的共同危险因素包括孕周和长时间氧疗。多因素分析显示，孕周（比值比：4.44；95%置信区间：3-6.57）、插管复苏（比值比：2.35；95%置信区间：1.09-5.05）、机械通气时间≥7天（比值比：1.01；95%置信区间：1.01-1.01）和长时间总氧疗（比值比：3.13；95%置信区间：1.28-7.64）是BPD的独立危险因素。此外，孕周（比值比：0.66；95%置信区间：0.54-0.81）和长时间氧疗（比值比：1.02；95%置信区间：1-1.03）是ROP的独立危险因素。：适当控制氧疗的持续时间和浓度，同时尽量缩短机械通气时间，对于降低BPD和ROP的发生率至关重要。
