Drago F, Valerio C, D'Agata V, Astuto C, Spadaro F, Continella G, Scapagnini U
Institute of Pharmacology, University of Catania Medical School, Italy.
Funct Neurol. 1988 Apr-Jun;3(2):137-43.
The effects of the arginine salt of pyroglutamic acid (2-oxo-pyrrolidone carboxylic acid, PCA) on learning and memory capacities of old rats were studied in a subchronic treatment schedule (i.p. injection of 0.1 and 1 g/kg/day for 15 days). The acquisition and extinction of active avoidance behaviour were studied in a pole-jumping test situation. The retention of passive avoidance response was examined in a step-through passive avoidance task. PCA facilitated the rate of acquisition of pole-jumping response, and inhibited the extinction of the response. The dose of 1 g/kg was more potent than 0.1 g/kg in this respect. Also in the passive avoidance task, the treatment with PCA was followed by an improvement of avoidance retention. These results indicate that PCA is a behaviourally active compound in that it improves learning and memory capacities in old rat.
采用亚慢性给药方案（腹腔注射，剂量为0.1和1 g/kg/天，持续15天），研究了焦谷氨酸精氨酸盐（2-氧代-吡咯烷酮羧酸，PCA）对老年大鼠学习和记忆能力的影响。在跳杆试验中研究了主动回避行为的获得和消退。在穿梭式被动回避任务中检测了被动回避反应的保持情况。PCA促进了跳杆反应的获得速率，并抑制了该反应的消退。在这方面，1 g/kg的剂量比0.1 g/kg更有效。同样在被动回避任务中，PCA处理后回避保持能力得到改善。这些结果表明，PCA是一种具有行为活性的化合物，因为它能改善老年大鼠的学习和记忆能力。
