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[An experimental study of the psychotropic effects of aspartic acid from the aspect of age].

作者信息

Kovalev G V, Sazhin V A, Skazkina T G, Ianitskaia A V

出版信息

Farmakol Toksikol. 1990 Jan-Feb;53(1):22-5.

PMID:2328796
Abstract

After acute injections to adult and 90-day old rats aspartic acid in doses of 100-500 mg/kg increased the locomotor and exploratory activity during the open-field test and in a dose of 100 mg/kg exerted the antidepressant effect during the forced swimming test. Following treatment for 10 days the amino acid in a dose of 10 mg/kg disrupted acquisition of passive avoidance reaction of young rats and in a dose of 100 mg/kg inhibited learning of active avoidance reaction in adult rats.

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