Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
Br J Pharmacol. 2022 Sep;179(17):4281-4299. doi: 10.1111/bph.15569. Epub 2021 Jun 24.
Mesenchymal stem/stromal cells (MSCs) are multipotent progenitor cells of mesodermal origin. Due to their capacity for self-renewal and differentiation into several cell types, MSCs have been extensively studied in experimental biology and regenerative medicine in recent years. Moreover, MSCs release extracellular vesicles (EVs), which might be partly responsible for their regenerative properties. MSCs regulate several processes in target cells via paracrine signalling, such as immunomodulation, anti-apoptotic signalling, tissue remodelling, angiogenesis and anti-fibrotic signalling. The aim of this review is to provide a detailed description of the functional properties of MSCs and EVs and their potential clinical applications, with a special focus on pain treatment. The analgesic, anti-inflammatory and regenerative properties of MSCs and EVs will be discussed for several diseases, such as neuropathic pain, osteoarthritis and spinal cord injury. LINKED ARTICLES: This article is part of a themed issue on New discoveries and perspectives in mental and pain disorders. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.17/issuetoc.
间充质干细胞（MSCs）是中胚层来源的多能祖细胞。由于其自我更新和分化为多种细胞类型的能力，MSCs 近年来在实验生物学和再生医学中得到了广泛研究。此外，MSCs 释放细胞外囊泡（EVs），这可能部分解释了它们的再生特性。MSCs 通过旁分泌信号调节靶细胞中的几种过程，如免疫调节、抗细胞凋亡信号、组织重塑、血管生成和抗纤维化信号。本综述的目的是详细描述 MSCs 和 EVs 的功能特性及其潜在的临床应用，特别是在疼痛治疗方面。将讨论 MSCs 和 EVs 在几种疾病中的镇痛、抗炎和再生特性，如神经病理性疼痛、骨关节炎和脊髓损伤。
本文是关于精神和疼痛障碍新发现和新视角的专题的一部分。要查看本节中的其他文章，请访问 http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.17/issuetoc.
