Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, PR China.
Zhejiang Conba Pharmaceutical Limited Company, Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Hangzhou, 310052, PR China.
Food Chem Toxicol. 2021 Jul;153:112289. doi: 10.1016/j.fct.2021.112289. Epub 2021 May 21.
Fritillaria thunbergii Miq. (Zhe beimu) ranked as oldest known homeopathic traditional folk medicine in China. The bulbs are medicinally important curing cough, inflammation, gastric ulcers, hypertension, diarrhea, and bronchitis. The aim of this review is to enlighten the deeper knowledge about F. thunbergii giving a comprehensive overview on its traditional uses, phytochemistry and pharmacology for future investigation of plant-based drugs and therapeutic applications. Total 48 medicinally important species of Fritillaria were described; total 122 compounds have been identified as results only 72 chemical constituents were described with proper chemical and biological details. F. thunbergii and its bulbs mainly constitute alkaloids, essential oils, diterpenoids, carbohydrates, sterols, amino acids, nucleosides, fatty acids, and lignans. The pharmacological studies demonstrate that F. thunbergii and its bulbs displays a wide range of bioactivities e.g., anti-inflammatory, anticancer, antitussive, expectorant, anti-ulcer, antimicrobial, antioxidant, anti-thyroid, regulation of blood rheology, anti-diarrhea, neuroprotection, and analgesic effects. Although promising reports on the various chemical bioactive constituents and biological properties of F. thunbergii have been published, very few reviews are related specifically to the traditional uses, phytochemistry and pharmacological applications. Further, various other studies on these plants should deserve our more attention for future investigation for drug development and its therapeutic applications.
浙贝母（Fritillaria thunbergii Miq.）是中国最古老的已知顺势疗法传统民间药物。其鳞茎具有药用价值，可治疗咳嗽、炎症、胃溃疡、高血压、腹泻和支气管炎。本综述旨在阐明关于 F. thunbergii 的更深入知识，全面概述其传统用途、植物化学和药理学，为未来基于植物的药物和治疗应用的研究提供参考。描述了总共 48 种具有药用价值的贝母属植物；总共鉴定出 122 种化合物，但只有 72 种化学成分具有适当的化学和生物学细节。F. thunbergii 及其鳞茎主要由生物碱、精油、二萜、碳水化合物、甾醇、氨基酸、核苷、脂肪酸和木脂素组成。药理研究表明，F. thunbergii 及其鳞茎具有广泛的生物活性，如抗炎、抗癌、止咳、祛痰、抗溃疡、抗菌、抗氧化、抗甲状腺、调节血液流变学、抗腹泻、神经保护和镇痛作用。尽管已经发表了关于 F. thunbergii 的各种化学成分和生物活性的有前景的报告，但专门针对其传统用途、植物化学和药理学应用的综述很少。此外，我们应该更加关注这些植物的其他各种研究，以促进药物开发和治疗应用。
