Int J Epidemiol. 1988 Jun;17(2):263-9.
This is a report on the relationship of combined oral contraceptives to risk of endometrial cancer from a multinational hospital-based case-control study of various steroid contraceptives and five different cancers. Based on data on 130 cases and 835 matched controls from nine participating centres in seven developing countries and two participating centres in two developed countries, the relative risk of endometrial carcinoma in women who ever took combined oral contraceptives was estimated to be 0.55. This value is similar to estimates from prior investigations in the US and Italy, and the protective effect observed in this study was at least as great in the developing countries with low incidence rates as in the developed countries with higher rates. The reduction in risk was observed for adenocarcinomas with and without squamous elements.
这是一份关于复方口服避孕药与子宫内膜癌风险关系的报告，该报告来自一项针对多种甾体避孕药和五种不同癌症的跨国医院病例对照研究。基于来自七个发展中国家的九个参与中心以及两个发达国家的两个参与中心的130例病例和835例匹配对照的数据，曾服用复方口服避孕药的女性患子宫内膜癌的相对风险估计为0.55。该值与美国和意大利先前调查的估计值相似，并且在本研究中观察到的保护作用在发病率较低的发展中国家至少与发病率较高的发达国家一样大。对于有和没有鳞状成分的腺癌，均观察到风险降低。
