Coe C L, Rosenberg L T, Levine S
Department of Psychology, University of Wisconsin, Madison 53706.
Int J Neurosci. 1988 Jun;40(3-4):289-302. doi: 10.3109/00207458808990717.
Hemolytic complement activity and complement protein levels were evaluated before and after psychological disturbance in the squirrel monkey. Significant increases in hemolytic complement activity were observed following separation of 6-month-old infants from their mothers. Complement protein levels were generally correlated with hemolytic activity, but did not show the same pattern of change. C3 levels did not change consistently after maternal separation, while C4 decreased significantly on Day 7, and then began to return toward basal levels by Day 14. The alterations in complement activity were associated with elevated adrenal hormone secretion, but were not directly correlated with plasma cortisol levels. A second experiment showed that increased hemolytic complement activity also occurred in juvenile squirrel monkeys following 4-hour to 7-day removals from a peer group. The effect of maternal separation on antibody responses to viral challenge was evaluated in a third experiment. Separated infant squirrel monkeys mounted a smaller antibody response than did control infants that remained with their mothers. A similar decline in antibody responses was observed in separated rhesus macaque infants, but the effect was less marked in this species. Thus, the strong effect of psychological disturbance on immunity in the squirrel monkey is probably related to its prolonged endocrine responses.
在松鼠猴中，对心理干扰前后的溶血补体活性和补体蛋白水平进行了评估。在6个月大的幼猴与其母亲分离后，观察到溶血补体活性显著增加。补体蛋白水平通常与溶血活性相关，但未表现出相同的变化模式。母体分离后，C3水平并非始终保持一致的变化，而C4在第7天显著下降，然后在第14天开始向基础水平回升。补体活性的改变与肾上腺激素分泌增加有关，但与血浆皮质醇水平无直接关联。第二项实验表明，将幼年松鼠猴从同伴群体中移除4小时至7天后，其溶血补体活性也会增加。在第三项实验中，评估了母体分离对病毒攻击抗体反应的影响。与母亲在一起的对照幼猴相比，被分离的幼松鼠猴产生的抗体反应较小。在被分离的恒河猴幼猴中也观察到了类似的抗体反应下降，但在该物种中这种影响不太明显。因此，心理干扰对松鼠猴免疫力的强烈影响可能与其长期的内分泌反应有关。
