Kanemoto Kazuya, Horikawa Nao, Hoshino Shun, Tokoro Yuichiro, Fukuzawa Shin-Ichi
Department of Applied Chemistry, Institute of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.
Org Lett. 2021 Jul 2;23(13):4966-4970. doi: 10.1021/acs.orglett.1c01294. Epub 2021 May 25.
An unprecedented copper-catalyzed C-H monoamination of ferrocenes directed by an 8-aminoquinoline amide directing group is described. This reaction proceeds in the presence of a catalytic amount of copper catalyst with both cyclic and acyclic amines to afford the various aminoferrocenes. The C-H amination of -substituted ferroceneamides was also achieved, enabling rapid access to multisubstituted ferrocenes that are useful for developing new functional molecules.
描述了一种由8-氨基喹啉酰胺导向基团导向的前所未有的铜催化二茂铁的C-H单胺化反应。该反应在催化量的铜催化剂存在下，与环状和非环状胺反应，生成各种氨基二茂铁。还实现了β-取代二茂铁酰胺的C-H胺化反应，能够快速获得可用于开发新功能分子的多取代二茂铁。
