Department of Orthopaedics, the First Affiliated Hospital of University of Science and Technology of China, Hefei, People's Republic of China.
Medicine (Baltimore). 2021 May 28;100(21):e25645. doi: 10.1097/MD.0000000000025645.
Since December 2019, pneumonia caused by a novel coronavirus (SARS-CoV-2), namely 2019 novel coronavirus disease (COVID-19), has rapidly spread from Wuhan city to other cities across China. The present study was designed to describe the epidemiology, clinical characteristics, treatment, and prognosis of 74 hospitalized patients with COVID-19.Clinical data of 74 COVID-19 patients were collected to analyze the epidemiological, demographic, laboratory, radiological, and treatment data. Thirty-two patients were followed up and tested for the presence of the viral nucleic acid and by pulmonary computed tomography (CT) scan at 7 and 14 days after they were discharged.Among all COVID-19 patients, the median incubation period for patients and the median period from symptom onset to admission was all 6 days; the median length of hospitalization was 13 days. Fever symptoms were presented in 83.78% of the patients, and the second most common symptom was cough (74.32%), followed by fatigue and expectoration (27.03%). Inflammatory indicators, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) of the intensive care unit (ICU) patients were significantly higher than that of the non-ICU patients (P < .05). However, 50.00% of the ICU patients had their the ratio of T helper cells to cytotoxic T cells (CD4/CD8) ratio lower than 1.1, whose proportion is much higher than that in non-ICU patients (P < .01).Compared with patients in Wuhan, COVID-19 patients in Anhui Province seemed to have milder symptoms of infection, suggesting that there may be some regional differences in the transmission of SARS-CoV-2 between different cities.
自 2019 年 12 月以来，一种新型冠状病毒（SARS-CoV-2）引起的肺炎，即 2019 年新型冠状病毒病（COVID-19），已迅速从武汉市蔓延至中国其他城市。本研究旨在描述 74 例 COVID-19 住院患者的流行病学、临床特征、治疗和预后。收集了 74 例 COVID-19 患者的临床资料，分析了流行病学、人口统计学、实验室、影像学和治疗数据。对 32 例患者进行了随访，并在出院后 7 天和 14 天检测了病毒核酸和肺部计算机断层扫描（CT）扫描。在所有 COVID-19 患者中，患者的中位潜伏期和症状出现到入院的中位时间均为 6 天；中位住院时间为 13 天。发热症状见于 83.78%的患者，其次是咳嗽（74.32%），其次是疲劳和咳痰（27.03%）。重症监护病房（ICU）患者的炎症指标、红细胞沉降率（ESR）和 C 反应蛋白（CRP）明显高于非 ICU 患者（P<.05）。然而，50.00%的 ICU 患者的辅助性 T 细胞与细胞毒性 T 细胞（CD4/CD8）比值低于 1.1，其比例明显高于非 ICU 患者（P<.01）。与武汉患者相比，安徽省 COVID-19 患者的感染症状似乎较轻，这表明不同城市之间 SARS-CoV-2 的传播可能存在一些区域性差异。
